4-[2-(4-fluoro-phenyl)-7-piperidin-4-yl-imidazo[1,2-a]pyridin-3-yl]-pyrimidin-2-ylamine

Base Information

Chemical Name:4-[2-(4-fluoro-phenyl)-7-piperidin-4-yl-imidazo[1,2-a]pyridin-3-yl]-pyrimidin-2-ylamine
CAS No.:762172-80-5
Molecular Formula:C₂₂H₂₁FN₆
Molecular Weight:388.447
Hs Code.:

4-[2-(4-fluoro-phenyl)-7-piperidin-4-yl-imidazo[1,2-<i>a</i>]pyridin-3-yl]-pyrimidin-2-ylamine

Synonyms:4-[2-(4-fluoro-phenyl)-7-piperidin-4-yl-imidazo[1,2-a]pyridin-3-yl]-pyrimidin-2-ylamine

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Chemical Property of 4-[2-(4-fluoro-phenyl)-7-piperidin-4-yl-imidazo[1,2-a]pyridin-3-yl]-pyrimidin-2-ylamine

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Technology Process of 4-[2-(4-fluoro-phenyl)-7-piperidin-4-yl-imidazo[1,2-a]pyridin-3-yl]-pyrimidin-2-ylamine

There total 6 articles about 4-[2-(4-fluoro-phenyl)-7-piperidin-4-yl-imidazo[1,2-a]pyridin-3-yl]-pyrimidin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1042443-06-0
1-{4-[3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]piperidin-4-yl}ethanone

: 762172-80-5
4-[2-(4-fluoro-phenyl)-7-piperidin-4-yl-imidazo[1,2-a]pyridin-3-yl]-pyrimidin-2-ylamine

Guidance literature:: With hydrogenchloride; at 90 ℃; for 12h;
DOI:10.1016/j.ejmech.2007.09.013

Reference yield:

: 2-chloro-1-(4-fluoro-phenyl)-ethanone O-methyl-oxime

: 762172-80-5
4-[2-(4-fluoro-phenyl)-7-piperidin-4-yl-imidazo[1,2-a]pyridin-3-yl]-pyrimidin-2-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1: LiBr

2: potassium tert-butoxide

3: sulfuric acid

4: N,N-dimethyl-acetamide

5: sodium methoxide

6: H₂ / Pd/C

With sulfuric acid; potassium tert-butylate; hydrogen; sodium methylate; lithium bromide; palladium on activated charcoal; In N,N-dimethyl acetamide;
DOI:10.1016/j.bmcl.2006.01.092

Reference yield:

: 2-bromo-1-(4-fluorophenyl)ethanone O-methyloxime

: 762172-80-5
4-[2-(4-fluoro-phenyl)-7-piperidin-4-yl-imidazo[1,2-a]pyridin-3-yl]-pyrimidin-2-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1: potassium tert-butoxide

2: sulfuric acid

3: N,N-dimethyl-acetamide

4: sodium methoxide

5: H₂ / Pd/C

With sulfuric acid; potassium tert-butylate; hydrogen; sodium methylate; palladium on activated charcoal; In N,N-dimethyl acetamide;
DOI:10.1016/j.bmcl.2006.01.092