5-(1-((2-(ethylamino)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)-N-(4-fluorophenyl)pyrimidine-2-carboxamide

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Chemical Name:5-(1-((2-(ethylamino)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)-N-(4-fluorophenyl)pyrimidine-2-carboxamide
CAS No.:1421472-38-9
Molecular Formula:C₂₃H₂₂F₄N₆O₂
Molecular Weight:490.46
Hs Code.:

Synonyms:5-(1-((2-(ethylamino)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)-N-(4-fluorophenyl)pyrimidine-2-carboxamide

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Chemical Property of 5-(1-((2-(ethylamino)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)-N-(4-fluorophenyl)pyrimidine-2-carboxamide

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Technology Process of 5-(1-((2-(ethylamino)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)-N-(4-fluorophenyl)pyrimidine-2-carboxamide

There total 9 articles about 5-(1-((2-(ethylamino)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)-N-(4-fluorophenyl)pyrimidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1419603-30-7
2-(2-(4-fluorophenylcarbamoyl)pyrimidin-5-yl)propanoic acid

: 1421472-45-8
3-(aminomethyl)-N-ethyl-6-(trifluoromethyl)pyridin-2-amine

: 1421472-38-9
5-(1-((2-(ethylamino)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)-N-(4-fluorophenyl)pyrimidine-2-carboxamide

Guidance literature:: With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In tetrahydrofuran; for 24h;

Reference yield:

: 37131-87-6
5-bromo-2-pyrimidinecarboxylic acid

: 1421472-38-9
5-(1-((2-(ethylamino)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)-N-(4-fluorophenyl)pyrimidine-2-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / benzene / 2 h / 100 °C

2.1: dichloromethane / 16 h / 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -5 °C / Inert atmosphere

3.2: 2 h / -5 - 20 °C

4.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

5.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Inert atmosphere

6.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 2585.81 Torr / Inert atmosphere

7.1: hydrogenchloride; water / ethanol / 2 h / 90 °C

8.1: benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 24 h

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; palladium 10% on activated carbon; water; hydrogen; potassium acetate; sodium hydride; sodium carbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; benzene;

Reference yield:

: 1419603-19-2
5-bromo-N-(4-fluorophenyl)pyrimidine-2-carboxamide

: 1421472-38-9
5-(1-((2-(ethylamino)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)-N-(4-fluorophenyl)pyrimidine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -5 °C / Inert atmosphere

1.2: 2 h / -5 - 20 °C

2.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 2585.81 Torr / Inert atmosphere

5.1: hydrogenchloride; water / ethanol / 2 h / 90 °C

6.1: benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 24 h

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; water; hydrogen; potassium acetate; sodium hydride; sodium carbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In tetrahydrofuran; 1,4-dioxane; ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;