2-(5-(3-aminopyridin-4-yl)-3,3-dimethylcyclohexyl)isoindoline-1,3-dione

Base Information

Chemical Name:2-(5-(3-aminopyridin-4-yl)-3,3-dimethylcyclohexyl)isoindoline-1,3-dione
CAS No.:1187055-90-8
Molecular Formula:C₂₁H₂₃N₃O₂
Molecular Weight:349.433
Hs Code.:

Synonyms:2-(5-(3-aminopyridin-4-yl)-3,3-dimethylcyclohexyl)isoindoline-1,3-dione

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Chemical Property of 2-(5-(3-aminopyridin-4-yl)-3,3-dimethylcyclohexyl)isoindoline-1,3-dione

Chemical Property:

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Technology Process of 2-(5-(3-aminopyridin-4-yl)-3,3-dimethylcyclohexyl)isoindoline-1,3-dione

There total 8 articles about 2-(5-(3-aminopyridin-4-yl)-3,3-dimethylcyclohexyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1187055-89-5
2-(3-(3-aminopyridin-4-yl)-5,5-dimethyl-cyclohex-2-enyl)isoindoline-1,3-dione

: 1187055-90-8
2-(5-(3-aminopyridin-4-yl)-3,3-dimethylcyclohexyl)isoindoline-1,3-dione

Guidance literature:: With hydrogen; acetic acid; palladium 10% on activated carbon; at 45 - 65 ℃; under 15514.9 Torr;

Reference yield:

: 1187055-86-2
5,5-dimethyl-3-(3-nitropyridin-4-yl)cyclohex-2-enone

: 1187055-90-8
2-(5-(3-aminopyridin-4-yl)-3,3-dimethylcyclohexyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate; cerium(III) chloride / methanol / 1 h / 0 °C

2: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 0 °C

3: hydrogen; acetic acid / palladium 10% on activated carbon / 20 °C

4: hydrogen; acetic acid / palladium 10% on activated carbon / 45 - 65 °C / 15514.9 Torr

With sodium tetrahydroborate; cerium(III) chloride; di-tert-butyl-diazodicarboxylate; hydrogen; acetic acid; triphenylphosphine; palladium 10% on activated carbon; In tetrahydrofuran; methanol;

Reference yield:

: 1187055-87-3
5,5-dimethyl-3-(3-nitropyridin-4-yl)cyclohex-2-enol

: 1187055-90-8
2-(5-(3-aminopyridin-4-yl)-3,3-dimethylcyclohexyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 0 °C

2: hydrogen; acetic acid / palladium 10% on activated carbon / 20 °C

3: hydrogen; acetic acid / palladium 10% on activated carbon / 45 - 65 °C / 15514.9 Torr

With di-tert-butyl-diazodicarboxylate; hydrogen; acetic acid; triphenylphosphine; palladium 10% on activated carbon; In tetrahydrofuran;