(2-Methoxy-2-oxoethyl)triphenylphosphonium chloride

Base Information

• Chemical Name: (2-Methoxy-2-oxoethyl)triphenylphosphonium chloride
• CAS No.: 2181-97-7
• Molecular Formula: C21H20 O2 P . Cl
• Molecular Weight: 370.815
• Hs Code.: 2931900090
• European Community (EC) Number: 606-843-6
• DSSTox Substance ID: DTXSID90369936
• Mol file: 2181-97-7.mol

Synonyms:2181-97-7;(2-Methoxy-2-oxoethyl)triphenylphosphonium chloride;CARBOMETHOXYMETHYL TRIPHENYLPHOSPHONIUM CHLORIDE;(Methoxycarbonylmethyl)triphenylphosphonium chloride;(2-methoxy-2-oxoethyl)-triphenylphosphanium;chloride;MFCD00050199;SCHEMBL477563;DTXSID90369936;CAA18197;AKOS015913154;CS-0333592;FT-0623467;D95945;A815681;(2-methoxy-2-oxoethyl)-triphenylphosphonium chloride;(2-Methoxy-2-oxoethyl)(triphenyl)phosphanium chloride;Carbmethoxymethyl triphenyl phosphonium Chloride (CMMTPPC);Phosphonium,(2-methoxy-2-oxoethyl)triphenyl-,chloride(1:1);(2-methoxy-2-oxidanylidene-ethyl)-triphenyl-phosphanium chloride

Chemical Property of (2-Methoxy-2-oxoethyl)triphenylphosphonium chloride

Chemical Property:

• Appearance/Colour: white fine crystalline powder
• Melting Point: 155 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 39.89000
• Density: g/cm³
• LogP: 0.15750
• Storage Temp.: 0-6°C
• Sensitive.: Hygroscopic
• Water Solubility.: Very Soluble in water (100 g/L) (25°C).
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 370.0889446
• Heavy Atom Count: 25
• Complexity: 345

Purity/Quality:

99% ^*data from raw suppliers

(Methoxycarbonylmethyl)tris(phenyl)phosphonium chloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-36

MSDS Files:

Useful:

• Canonical SMILES: COC(=O)C[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3.[Cl-]
• Uses: It is employed as intermediate for pharmaceutical.

Technology Process of (2-Methoxy-2-oxoethyl)triphenylphosphonium chloride

There total 25 articles about (2-Methoxy-2-oxoethyl)triphenylphosphonium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

trans-tetrachlorobis(pyridine)platinum(II) (16893-32-6,17100-03-7,19306-93-5) + methyl (triphenylphosphoranylidene)acetate (21204-67-1,2605-67-6) → trans-dichlorobis(pyridine)platinum(II) (14024-97-6,14872-21-0,15227-42-6) + (2-methoxy-2-oxoethyl)triphenylphosphonium chloride (2181-97-7) + Triphenylphosphine oxide (791-28-6)

Guidance literature:

In dichloromethane; Ph3P=CHCO2Me was added to soln. Pt(IV) complex in CH2Cl2, react. mixt. was kept at room temp. for 3 h; solvent was evapd., residue was chromed. on silica using CH2Cl2/Et2O (9:1) as eluent;

DOI:10.1021/ic000769c

Reference yield: 99.0%

trans-tetrachlorobis(dimethyl sulfide) platinum(IV) (16893-23-5,16893-33-7,55903-49-6) + methyl (triphenylphosphoranylidene)acetate (21204-67-1,2605-67-6) → trans-dichlorobis(dimethylsulfide)platinum(II) (17836-09-8,17457-51-1,55449-91-7) + (2-methoxy-2-oxoethyl)triphenylphosphonium chloride (2181-97-7) + Triphenylphosphine oxide (791-28-6)

Guidance literature:

In dichloromethane; Ph3P=CHCO2Me was added to soln. Pt(IV) complex in CH2Cl2, react. mixt. was kept at room temp. for 3 h; solvent was evapd., residue was chromed. on silica using CH2Cl2/Et2O (9:1) as eluent;

DOI:10.1021/ic000769c

Reference yield: 99.0%

trans-(PtCl4(py)(SMe2)) (129090-07-9,129171-95-5,176895-88-8) + methyl (triphenylphosphoranylidene)acetate (21204-67-1,2605-67-6) → trans-dichloro(dimethyl sulfide-κS)(pyridine-κ-N)platinum(II) (31203-94-8,161345-43-3,31203-93-7) + (2-methoxy-2-oxoethyl)triphenylphosphonium chloride (2181-97-7) + Triphenylphosphine oxide (791-28-6)

Guidance literature:

In dichloromethane; Ph3P=CHCO2Me was added to soln. Pt(IV) complex in CH2Cl2, react. mixt. was kept at room temp. for 3 h; solvent was evapd., residue was chromed. on silica using CH2Cl2/Et2O (9:1) as eluent;

DOI:10.1021/ic000769c

upstream raw materials:

(Diphenylphoshino-methoxycarbonyl-methylen)-triphenyl-phosphoran

methyl chloroacetate

triphenylphosphine

methyl (triphenylphosphoranylidene)acetate

Downstream raw materials:

[Ph3PCH2COOMe][PtCl3(η(2)-C2H4)]

tert-butyl (S,E)-2-(4-(octyloxy)phenylcarbamoyl)-4-(methoxycarbonyl)but-3-en-2-ylcarbamate

methyl 2-cyclohexylideneacetate

(Z)-2-(prop-1-en-3-methoxycarbonyl)furane

Refernces

• 1、 Castaneda, Fernando,Aliaga, Christian,Acuna, Cristina,Silva, Paul,Bunton, Clifford A.. "Thermal decomposition of triphenylphosphonium alkyl ester salts". experimental part. p. 1188 - 1208. Retrieved 2009/04/16.
• 2、 Sanchez, Ignacio H.,Larraza, Maria Isabel,Brena, Francisco Kuri,Cruz, Adrian,Sotelo, Octavio,Flores, Humberto J.. "FACILE SYNTHESIS OF ALKYL 5-ALKOXY-3-OXOPENTANOATES". . p. 299 - 308. Retrieved 2007/10/02.