(4-ethyl-5-{5-[4-(2-fluorophenoxy)phenyl]-1,2,4-oxadiazol-3-yl}-2-thienyl)methanol

Base Information

Chemical Name:(4-ethyl-5-{5-[4-(2-fluorophenoxy)phenyl]-1,2,4-oxadiazol-3-yl}-2-thienyl)methanol
CAS No.:913828-85-0
Molecular Formula:C₂₁H₁₇FN₂O₃S
Molecular Weight:396.442
Hs Code.:

Synonyms:(4-ethyl-5-{5-[4-(2-fluorophenoxy)phenyl]-1,2,4-oxadiazol-3-yl}-2-thienyl)methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4-ethyl-5-{5-[4-(2-fluorophenoxy)phenyl]-1,2,4-oxadiazol-3-yl}-2-thienyl)methanol

Chemical Property:

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Technology Process of (4-ethyl-5-{5-[4-(2-fluorophenoxy)phenyl]-1,2,4-oxadiazol-3-yl}-2-thienyl)methanol

There total 13 articles about (4-ethyl-5-{5-[4-(2-fluorophenoxy)phenyl]-1,2,4-oxadiazol-3-yl}-2-thienyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1028947-15-0
C₂₇H₃₁FN₂O₃SSi

: 913828-85-0
(4-ethyl-5-{5-[4-(2-fluorophenoxy)phenyl]-1,2,4-oxadiazol-3-yl}-2-thienyl)methanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2011.12.019

Reference yield:

: 913828-84-9
4-(2-fluorophenoxy)benzoic acid

: 913828-85-0
(4-ethyl-5-{5-[4-(2-fluorophenoxy)phenyl]-1,2,4-oxadiazol-3-yl}-2-thienyl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol / acetonitrile

2: tetrabutyl ammonium fluoride / tetrahydrofuran

With tetrabutyl ammonium fluoride; benzotriazol-1-ol; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.bmcl.2011.12.019

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 913828-85-0
(4-ethyl-5-{5-[4-(2-fluorophenoxy)phenyl]-1,2,4-oxadiazol-3-yl}-2-thienyl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 100 °C

2: sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; water / tetrahydrofuran; tert-butyl alcohol

3: benzotriazol-1-ol / acetonitrile

4: tetrabutyl ammonium fluoride / tetrahydrofuran

With sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; tetrabutyl ammonium fluoride; water; potassium carbonate; benzotriazol-1-ol; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 2: Pinnick oxidation;
DOI:10.1016/j.bmcl.2011.12.019