N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-serinamide hydrochloride

Base Information

Chemical Name:N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-serinamide hydrochloride
CAS No.:1269408-25-4
Molecular Formula:C₁₄H₁₇N₅O₄*ClH
Molecular Weight:355.781
Hs Code.:

N<sub>1</sub>-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-serinamide hydrochloride

Synonyms:N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-serinamide hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-serinamide hydrochloride

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Technology Process of N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-serinamide hydrochloride

There total 4 articles about N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-serinamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1269406-89-4
1,1-dimethylethyl [(1S)-2-{[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]amino}-1-(hydroxymethyl)-2-oxoethyl]carbamate

: 1269408-25-4
N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-serinamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 40 - 50 ℃; for 19h;

Reference yield:

: 17417-09-3
2-fluoro-5-nitrobenzonitrile

: 1269408-25-4
N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-serinamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 1 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: triethylamine; HATU / dichloromethane / 2 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 19 h / 40 - 50 °C

With hydrogenchloride; potassium carbonate; triethylamine; HATU; In 1,4-dioxane; dichloromethane; acetonitrile;

Reference yield:

: 1269406-69-0
1,1-dimethylethyl [(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]carbamate

: 1269408-25-4
N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-serinamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2: triethylamine; HATU / dichloromethane / 2 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 19 h / 40 - 50 °C

With hydrogenchloride; triethylamine; HATU; In 1,4-dioxane; dichloromethane;