2-<2-(3-methoxycarbonyl-1-propyloxy)phenyl>-5-diphenylmethyloxybenzofuran

Base Information

• Chemical Name: 2-<2-(3-methoxycarbonyl-1-propyloxy)phenyl>-5-diphenylmethyloxybenzofuran
• CAS No.: 190785-83-2
• Molecular Formula: C₃₂H₂₈O₅
• Molecular Weight: 492.571

Synonyms:2-<2-(3-methoxycarbonyl-1-propyloxy)phenyl>-5-diphenylmethyloxybenzofuran

Chemical Property of 2-<2-(3-methoxycarbonyl-1-propyloxy)phenyl>-5-diphenylmethyloxybenzofuran

Chemical Property:

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Technology Process of 2-<2-(3-methoxycarbonyl-1-propyloxy)phenyl>-5-diphenylmethyloxybenzofuran

There total 7 articles about 2-<2-(3-methoxycarbonyl-1-propyloxy)phenyl>-5-diphenylmethyloxybenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-hydroxyphenyl)-5-formylbenzofuran (190786-01-7) → 2-<2-(3-methoxycarbonyl-1-propyloxy)phenyl>-5-diphenylmethyloxybenzofuran (190785-83-2)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.) NaH / 1.) DMF, RT, 15 min, 2.) DMF, RT, 2 h

2: 88 percent / NaClO₂, NaH₂PO₄, 2-methyl-2-butene / N,N-dimethyl-acetamide; H₂O / 2 h / Ambient temperature

3: 1.) diphenylphosphoryl azide, Et₃N / 1.) toluene, reflux, 2 h, 2.) toluene, reflux, 8 h

4: 85 percent / H₂ / 10 percent Pd/C / methanol / 1 h / Ambient temperature

5: 1.) aq. NaNO₂, H₂SO₄, 2.) urea, 3.) aq. Na₂SO₄, H₂SO₄

6: concd. H₂SO₄ / 0.5 h / Heating

7: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 3 h

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; sulfuric acid; diphenylphosphoranyl azide; hydrogen; sodium hydride; sodium sulfate; triethylamine; urea; sodium nitrite; palladium on activated charcoal; In methanol; N,N-dimethyl acetamide; water;

DOI:10.1248/cpb.47.226

Reference yield:

2-<2-(3-ethoxycarbonyl-1-propyloxy)phenyl>-5-formylbenzofuran (190786-03-9) → 2-<2-(3-methoxycarbonyl-1-propyloxy)phenyl>-5-diphenylmethyloxybenzofuran (190785-83-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 88 percent / NaClO₂, NaH₂PO₄, 2-methyl-2-butene / N,N-dimethyl-acetamide; H₂O / 2 h / Ambient temperature

2: 1.) diphenylphosphoryl azide, Et₃N / 1.) toluene, reflux, 2 h, 2.) toluene, reflux, 8 h

3: 85 percent / H₂ / 10 percent Pd/C / methanol / 1 h / Ambient temperature

4: 1.) aq. NaNO₂, H₂SO₄, 2.) urea, 3.) aq. Na₂SO₄, H₂SO₄

5: concd. H₂SO₄ / 0.5 h / Heating

6: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 3 h

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; sulfuric acid; diphenylphosphoranyl azide; hydrogen; sodium hydride; sodium sulfate; triethylamine; urea; sodium nitrite; palladium on activated charcoal; In methanol; N,N-dimethyl acetamide; water;

DOI:10.1248/cpb.47.226

Reference yield:

2-<2-(3-ethoxycarbonyl-1-propyloxy)phenyl>benzofuran-5-carboxylic acid (190785-43-4) → 2-<2-(3-methoxycarbonyl-1-propyloxy)phenyl>-5-diphenylmethyloxybenzofuran (190785-83-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) diphenylphosphoryl azide, Et₃N / 1.) toluene, reflux, 2 h, 2.) toluene, reflux, 8 h

2: 85 percent / H₂ / 10 percent Pd/C / methanol / 1 h / Ambient temperature

3: 1.) aq. NaNO₂, H₂SO₄, 2.) urea, 3.) aq. Na₂SO₄, H₂SO₄

4: concd. H₂SO₄ / 0.5 h / Heating

5: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 3 h

With sulfuric acid; diphenylphosphoranyl azide; hydrogen; sodium hydride; sodium sulfate; triethylamine; urea; sodium nitrite; palladium on activated charcoal; In methanol;

DOI:10.1248/cpb.47.226

upstream raw materials:

Bromodiphenylmethane

2-<2-(3-methoxycarbonyl-1-propyloxy)phenyl>-5-hydroxybenzofuran

2-(2-hydroxyphenyl)-5-formylbenzofuran

2-<2-(3-ethoxycarbonyl-1-propyloxy)phenyl>-5-formylbenzofuran

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