4-{2-[5-(4-fluorophenyl)thiazol-2-ylamino]pyridin-4-ylmethyl}piperidine-1-carboxylic acid tertbutyl ester

Base Information

Chemical Name:4-{2-[5-(4-fluorophenyl)thiazol-2-ylamino]pyridin-4-ylmethyl}piperidine-1-carboxylic acid tertbutyl ester
CAS No.:1415812-08-6
Molecular Formula:C₂₅H₂₉FN₄O₂S
Molecular Weight:468.595
Hs Code.:

Synonyms:4-{2-[5-(4-fluorophenyl)thiazol-2-ylamino]pyridin-4-ylmethyl}piperidine-1-carboxylic acid tertbutyl ester

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Chemical Property of 4-{2-[5-(4-fluorophenyl)thiazol-2-ylamino]pyridin-4-ylmethyl}piperidine-1-carboxylic acid tertbutyl ester

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Technology Process of 4-{2-[5-(4-fluorophenyl)thiazol-2-ylamino]pyridin-4-ylmethyl}piperidine-1-carboxylic acid tertbutyl ester

There total 2 articles about 4-{2-[5-(4-fluorophenyl)thiazol-2-ylamino]pyridin-4-ylmethyl}piperidine-1-carboxylic acid tertbutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73040-69-4
N-(5-(4-fluorophenyl)thiazol-2-yl)acetamide

: 1415812-08-6
4-{2-[5-(4-fluorophenyl)thiazol-2-ylamino]pyridin-4-ylmethyl}piperidine-1-carboxylic acid tertbutyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water; 1,4-dioxane / 6 h / Reflux

2: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium carbonate / water; toluene / 16 h / Reflux; Inert atmosphere

With hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water; toluene;

Reference yield:

: 352-34-1
4-fluoro-1-iodobenzene

: 1415812-08-6
4-{2-[5-(4-fluorophenyl)thiazol-2-ylamino]pyridin-4-ylmethyl}piperidine-1-carboxylic acid tertbutyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate; palladium diacetate; tricyclohexylphosphine / N,N-dimethyl-formamide / 1 h / 140 °C / Microwave irradiation; Inert atmosphere

2: hydrogenchloride / water; 1,4-dioxane / 6 h / Reflux

3: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium carbonate / water; toluene / 16 h / Reflux; Inert atmosphere

With hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium phosphate; palladium diacetate; sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tricyclohexylphosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;