Boc-D-3-pyridylalanine-O-Benzyl-trans-4-hydroxy-L-proline-2-Aminoindane-2-carboxylic acid-Phenylalanine-NMe₂

Base Information

• Chemical Name: Boc-D-3-pyridylalanine-O-Benzyl-trans-4-hydroxy-L-proline-2-Aminoindane-2-carboxylic acid-Phenylalanine-NMe₂
• CAS No.: 1566599-09-4
• Molecular Formula: C₄₆H₅₄N₆O₇
• Molecular Weight: 802.971

Synonyms:Boc-D-3-pyridylalanine-O-Benzyl-trans-4-hydroxy-L-proline-2-Aminoindane-2-carboxylic acid-Phenylalanine-NMe₂

Chemical Property of Boc-D-3-pyridylalanine-O-Benzyl-trans-4-hydroxy-L-proline-2-Aminoindane-2-carboxylic acid-Phenylalanine-NMe₂

Chemical Property:

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Technology Process of Boc-D-3-pyridylalanine-O-Benzyl-trans-4-hydroxy-L-proline-2-Aminoindane-2-carboxylic acid-Phenylalanine-NMe₂

There total 8 articles about Boc-D-3-pyridylalanine-O-Benzyl-trans-4-hydroxy-L-proline-2-Aminoindane-2-carboxylic acid-Phenylalanine-NMe₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C33H38N4O4 + Boc-DPal (98266-33-2,105454-25-9) → Boc-D-3-pyridylalanine-O-Benzyl-trans-4-hydroxy-L-proline-2-Aminoindane-2-carboxylic acid-Phenylalanine-NMe2 (1566599-09-4)

Guidance literature:

With benzotriazol-1-ol; 1,2-dichloro-ethane; triethylamine; In dichloromethane; at 23 ℃; for 15h;

DOI:10.1021/ja412996f

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → Boc-D-3-pyridylalanine-O-Benzyl-trans-4-hydroxy-L-proline-2-Aminoindane-2-carboxylic acid-Phenylalanine-NMe2 (1566599-09-4)

Guidance literature:

Multi-step reaction with 7 steps

1: benzotriazol-1-ol; triethylamine; 1,2-dichloro-ethane / dichloromethane / 15 h / 20 °C

2: hydrogenchloride / water; 1,4-dioxane / 0.5 h / 23 °C / Inert atmosphere

3: benzotriazol-1-ol; triethylamine; 1,2-dichloro-ethane / dichloromethane / 15 h / 23 °C

4: lithium hydroxide monohydrate / water; tetrahydrofuran / 7 h / 23 °C

5: benzotriazol-1-ol; triethylamine; 1,2-dichloro-ethane / dichloromethane / 15 h / 23 °C

6: hydrogenchloride / water; 1,4-dioxane / 0.5 h / 23 °C / Inert atmosphere

7: benzotriazol-1-ol; triethylamine; 1,2-dichloro-ethane / dichloromethane / 15 h / 23 °C

With hydrogenchloride; lithium hydroxide monohydrate; benzotriazol-1-ol; 1,2-dichloro-ethane; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

DOI:10.1021/ja412996f

Reference yield:

Boc-O-Benzyl-trans-4-hydroxy-L-proline-(2-Aminoindane-2-carboxylic acid)-L-Phenylalanine-OMe → Boc-D-3-pyridylalanine-O-Benzyl-trans-4-hydroxy-L-proline-2-Aminoindane-2-carboxylic acid-Phenylalanine-NMe2 (1566599-09-4)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium hydroxide monohydrate / water; tetrahydrofuran / 7 h / 23 °C

2: benzotriazol-1-ol; triethylamine; 1,2-dichloro-ethane / dichloromethane / 15 h / 23 °C

3: hydrogenchloride / water; 1,4-dioxane / 0.5 h / 23 °C / Inert atmosphere

4: benzotriazol-1-ol; triethylamine; 1,2-dichloro-ethane / dichloromethane / 15 h / 23 °C

With hydrogenchloride; lithium hydroxide monohydrate; benzotriazol-1-ol; 1,2-dichloro-ethane; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

DOI:10.1021/ja412996f

upstream raw materials:

2-((tert-butoxycarbonyl)amino)-2,3-dihydro-1H-indene-2-carboxylic acid

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

Boc-2-Aminoindane-2-carboxylic acid-L-Phenylalanine-OMe

Boc-DPal

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