2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine

Base Information

• Chemical Name: 2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine
• CAS No.: 356065-71-9
• Molecular Formula: C₃₆H₃₆FN₅O₁₅
• Molecular Weight: 797.705

Synonyms:2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine

Chemical Property of 2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

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Technology Process of 2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine

There total 3 articles about 2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N4-{[2-(4-nitrophenyl)ethoxy]carbonyl}-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)cytidine (356065-62-8) → 2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N4-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine (356065-71-9)

Guidance literature:

DOI:10.1002/1522-2675(20010516)84:5<1066::AID-HLCA1066>3.0.CO;2-H

Reference yield:

N4-<2-(4-nitrophenyl)ethoxycarbonyl>-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)cytidine (155834-43-8) → 2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N4-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine (356065-71-9)

Guidance literature:

DOI:10.1002/1522-2675(20010516)84:5<1066::AID-HLCA1066>3.0.CO;2-H

Reference yield:

3-Fluoro-4-[2-(4-nitrophenyl)ethoxycarbonyloxy]benzyl vinyl ether (213548-00-6) → 2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N4-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine (356065-71-9)

Guidance literature:

DOI:10.1002/1522-2675(20010516)84:5<1066::AID-HLCA1066>3.0.CO;2-H

upstream raw materials:

2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)cytidine

N⁴-<2-(4-nitrophenyl)ethoxycarbonyl>-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)cytidine

3-Fluoro-4-[2-(4-nitrophenyl)ethoxycarbonyloxy]benzyl vinyl ether

Downstream raw materials:

5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine

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