2-(2-(tert-butyldimethylsilyloxy)ethoxy)-4-methoxy-5-nitropyridine

Base Information

• Chemical Name: 2-(2-(tert-butyldimethylsilyloxy)ethoxy)-4-methoxy-5-nitropyridine
• CAS No.: 1309686-51-8
• Molecular Formula: C₁₄H₂₄N₂O₅Si
• Molecular Weight: 328.44
• Mol file: 1309686-51-8.mol

Synonyms:2-(2-(tert-butyldimethylsilyloxy)ethoxy)-4-methoxy-5-nitropyridine

Chemical Property of 2-(2-(tert-butyldimethylsilyloxy)ethoxy)-4-methoxy-5-nitropyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(tert-butyldimethylsilyloxy)ethoxy)-4-methoxy-5-nitropyridine

There total 1 articles about 2-(2-(tert-butyldimethylsilyloxy)ethoxy)-4-methoxy-5-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-hydroxy-4-methoxy-5-nitro pyridine (607373-82-0) + 2-(tert-butyldimethylsilyloxy)ethyl bromide (86864-60-0) → 2-(2-(tert-butyldimethylsilyloxy)ethoxy)-4-methoxy-5-nitropyridine (1309686-51-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 2h;

Reference yield:

2-(2-(tert-butyldimethylsilyloxy)ethoxy)-4-methoxy-5-nitropyridine (1309686-51-8) → rac-(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid [6-(2-hydroxy-ethoxy)-4-methoxy-pyridin-3-yl]amide

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 0.75 h / 2585.81 Torr

2.1: N-ethyl-N,N-diisopropylamine; Diphenylphosphinic chloride / dichloromethane / 0.13 h / 20 °C

2.2: 48 h / 20 °C

3.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; water; hydrogen; N-ethyl-N,N-diisopropylamine; Diphenylphosphinic chloride; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; ethyl acetate;

upstream raw materials:

2-hydroxy-4-methoxy-5-nitro pyridine

2-(tert-butyldimethylsilyloxy)ethyl bromide