cis-4-{2-fluoro-4-[(2-{[3-fluoro-4-(trifluoromethyl)benzoyl]amino}ethyl)carbamoyl]phenoxy}cyclohexanecarboxylic acid

Base Information

• Chemical Name: cis-4-{2-fluoro-4-[(2-{[3-fluoro-4-(trifluoromethyl)benzoyl]amino}ethyl)carbamoyl]phenoxy}cyclohexanecarboxylic acid
• CAS No.: 1252878-15-1
• Molecular Formula: C₂₄H₂₃F₅N₂O₅
• Molecular Weight: 514.449
• Mol file: 1252878-15-1.mol

Synonyms:cis-4-{2-fluoro-4-[(2-{[3-fluoro-4-(trifluoromethyl)benzoyl]amino}ethyl)carbamoyl]phenoxy}cyclohexanecarboxylic acid

Chemical Property of cis-4-{2-fluoro-4-[(2-{[3-fluoro-4-(trifluoromethyl)benzoyl]amino}ethyl)carbamoyl]phenoxy}cyclohexanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-4-{2-fluoro-4-[(2-{[3-fluoro-4-(trifluoromethyl)benzoyl]amino}ethyl)carbamoyl]phenoxy}cyclohexanecarboxylic acid

There total 2 articles about cis-4-{2-fluoro-4-[(2-{[3-fluoro-4-(trifluoromethyl)benzoyl]amino}ethyl)carbamoyl]phenoxy}cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C26H27F5N2O5 → cis-4-{2-fluoro-4-[(2-{[3-fluoro-4-(trifluoromethyl)benzoyl]amino}ethyl)carbamoyl]phenoxy}cyclohexanecarboxylic acid (1252878-15-1)

Guidance literature:

C₂₆H₂₇F₅N₂O₅; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 50 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

ethyl cis-4-{4-[(2-aminoethyl)carbamoyl]-2-fluorophenoxy}cyclohexanecarboxylate hydrochloride (1252899-99-2) + 3-fluoro-4-(trifluoromethyl)benzoyl chloride (216144-68-2) → cis-4-{2-fluoro-4-[(2-{[3-fluoro-4-(trifluoromethyl)benzoyl]amino}ethyl)carbamoyl]phenoxy}cyclohexanecarboxylic acid (1252878-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 50 °C

With water; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

upstream raw materials:

ethyl cis-4-{4-[(2-aminoethyl)carbamoyl]-2-fluorophenoxy}cyclohexanecarboxylate hydrochloride

3-fluoro-4-(trifluoromethyl)benzoyl chloride