(2S,3S,4R,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2,7-dimethyl-4-octanolide

Base Information

• Chemical Name: (2S,3S,4R,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2,7-dimethyl-4-octanolide
• CAS No.: 145063-90-7
• Molecular Formula: C₃₂H₄₁NO₂Si
• Molecular Weight: 499.769
• Mol file: 145063-90-7.mol

Synonyms:(2S,3S,4R,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2,7-dimethyl-4-octanolide

Chemical Property of (2S,3S,4R,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2,7-dimethyl-4-octanolide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S,4R,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2,7-dimethyl-4-octanolide

There total 1 articles about (2S,3S,4R,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2,7-dimethyl-4-octanolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3S,4R,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2,7-dimethyl-4-octanolide (145064-16-0) → (2S,3S,4R,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2,7-dimethyl-4-octanolide (145063-90-7)

Guidance literature:

With malononitrile; lithium diisopropyl amide; Mechanism; multistep reaction, other acids;

DOI:10.1055/s-1992-26247

Reference yield: 62.0%

(2S,3S,4R,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2,7-dimethyl-4-octanolide (145063-90-7) → (2R,3E,5S)-5-dibenzylamino-2,7-dimethyl-3-octenoic acid (145063-93-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 70 ℃; for 6h;

DOI:10.1055/s-1992-26248

Reference yield: 44.0%

(2S,3S,4R,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2,7-dimethyl-4-octanolide (145063-90-7) → (2S,3S,4R,5S)-5-amino-3-dimethylphenylsilyl-2,7-dimethyl-4-octanolide (145063-91-8)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; for 26h;

DOI:10.1055/s-1992-26248

upstream raw materials:

(2R,3S,4R,5S)-5-dibenzylamino-3-dimethylphenylsilyl-2,7-dimethyl-4-octanolide

Downstream raw materials:

(2R,3E,5S)-5-dibenzylamino-2,7-dimethyl-3-octenoic acid

(3S,4R,5R)-5-((S)-1-Amino-3-methyl-butyl)-4-(dimethyl-phenyl-silanyl)-3-methyl-dihydro-furan-2-one

(2S,3S,4R,5S)-5-amino-3-dimethylphenylsilyl-2,7-dimethyl-4-octanolide

(2S,3S,4R,5S)-5-(tert-butoxycarbonylamino)-2,7-dimethyl-3-dimethylphenylsilyl-4-octanolide