C₁₆H₁₆O₃

Base Information

• Chemical Name: C₁₆H₁₆O₃
• CAS No.: 234097-59-7
• Molecular Formula: C₁₆H₁₆O₃
• Molecular Weight: 256.301
• Mol file: 234097-59-7.mol

Synonyms:C₁₆H₁₆O₃

Chemical Property of C₁₆H₁₆O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₆O₃

There total 6 articles about C₁₆H₁₆O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(+/-)-5-methoxycarbonyl-5-methyl-2-methoxy-2-Z-[ethyl-3-phenylprop-2-enoate]-2,5-dihydrofuran → C16H16O3 (234097-59-7)

Guidance literature:

With potassium hydroxide; In methanol;

DOI:10.1021/ol990532o

Reference yield:

C11H13BrO4 (234097-63-3) → C16H16O3 (234097-59-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 96 percent / tetrahydrofuran / 2 h / 0 °C

2.1: 61 percent / CaCO₃; Hg(ClO₄)2; H₂O / tetrahydrofuran / 0 °C

3.1: NaH / dimethylformamide / 1 h / 0 °C

3.2: dimethylformamide / 0 - 20 °C

3.3: 83 percent / dimethylformamide / 20 °C

4.1: 87 percent / KOH / methanol

With potassium hydroxide; mercury(II) perchlorate; water; sodium hydride; calcium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/ol990532o

Reference yield:

2-methoxy-5-methyl furan (37104-34-0) → C16H16O3 (234097-59-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 45 percent / benzene / 8 h / 80 °C

2.1: 96 percent / tetrahydrofuran / 2 h / 0 °C

3.1: 61 percent / CaCO₃; Hg(ClO₄)2; H₂O / tetrahydrofuran / 0 °C

4.1: NaH / dimethylformamide / 1 h / 0 °C

4.2: dimethylformamide / 0 - 20 °C

4.3: 83 percent / dimethylformamide / 20 °C

5.1: 87 percent / KOH / methanol

With potassium hydroxide; mercury(II) perchlorate; water; sodium hydride; calcium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; benzene; 1.1: Diels-Alder reaction;

DOI:10.1021/ol990532o

upstream raw materials:

C₁₁H₁₃BrO₄

2-methoxy-5-methyl furan

benzaldehyde