N-(10-{2-hydroxy-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-10H-phenothiazin-2-yl)acetamide

Base Information

Chemical Name:N-(10-{2-hydroxy-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-10H-phenothiazin-2-yl)acetamide
CAS No.:1442371-74-5
Molecular Formula:C₂₆H₂₆N₆O₃S
Molecular Weight:502.597
Hs Code.:

Synonyms:N-(10-{2-hydroxy-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-10H-phenothiazin-2-yl)acetamide

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Chemical Property of N-(10-{2-hydroxy-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-10H-phenothiazin-2-yl)acetamide

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Technology Process of N-(10-{2-hydroxy-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-10H-phenothiazin-2-yl)acetamide

There total 3 articles about N-(10-{2-hydroxy-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-10H-phenothiazin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1442371-92-7
N-[10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-10H-phenothiazin-2-yl]acetamide

: 1442371-74-5
N-(10-{2-hydroxy-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-10H-phenothiazin-2-yl)acetamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2013.04.034

Reference yield:

: 1387627-09-9
1-(2-chloro-10H-phenothiazin-10-yl)-4-(2-(4-methoxyphenyl)-2H-tetrazol-5-yl)butan-2-ol

: 1442371-74-5
N-(10-{2-hydroxy-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-10H-phenothiazin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / dichloromethane / 96 h / 0 - 20 °C / Inert atmosphere

2: XPhos / 22 h / 100 - 110 °C / Inert atmosphere; Alkaline conditions

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; tetrabutyl ammonium fluoride; XPhos; In tetrahydrofuran; dichloromethane; 2: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2013.04.034

Reference yield:

: 1442371-84-7
10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-2-chloro-10H-phenothiazine

: 1442371-74-5
N-(10-{2-hydroxy-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl}-10H-phenothiazin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: XPhos / 22 h / 100 - 110 °C / Inert atmosphere; Alkaline conditions

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; XPhos; In tetrahydrofuran; 1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2013.04.034