(3S)-1-((S)-(3,5-bis(trifluoromethyl)phenyl)(2-methyl-2H-tetrazol-5-yl)methyl)-3-ethyl-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline

Base Information

Chemical Name:(3S)-1-((S)-(3,5-bis(trifluoromethyl)phenyl)(2-methyl-2H-tetrazol-5-yl)methyl)-3-ethyl-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline
CAS No.:871834-72-9
Molecular Formula:C₂₂H₁₉F₉N₆
Molecular Weight:538.419
Hs Code.:

Synonyms:(3S)-1-((S)-(3,5-bis(trifluoromethyl)phenyl)(2-methyl-2H-tetrazol-5-yl)methyl)-3-ethyl-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline

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Chemical Property of (3S)-1-((S)-(3,5-bis(trifluoromethyl)phenyl)(2-methyl-2H-tetrazol-5-yl)methyl)-3-ethyl-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline

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Technology Process of (3S)-1-((S)-(3,5-bis(trifluoromethyl)phenyl)(2-methyl-2H-tetrazol-5-yl)methyl)-3-ethyl-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline

There total 10 articles about (3S)-1-((S)-(3,5-bis(trifluoromethyl)phenyl)(2-methyl-2H-tetrazol-5-yl)methyl)-3-ethyl-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871834-64-9
(S)-2-ethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline

: 871834-70-7
5-((3,5-bis(trifluoromethyl)phenyl)chloromethyl)-2-methyl-2H-tetrazole

: 871834-69-4
(3S)-1-((R)-(3,5-bis(trifluoromethyl)phenyl)(2-methyl-2H-tetrazol-5-yl)methyl)-3-ethyl-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline

: 871834-72-9
(3S)-1-((S)-(3,5-bis(trifluoromethyl)phenyl)(2-methyl-2H-tetrazol-5-yl)methyl)-3-ethyl-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 90 ℃; for 14h;

Reference yield:

: C₁₁H₁₃F₃N₂O₃

: 871834-72-9
(3S)-1-((S)-(3,5-bis(trifluoromethyl)phenyl)(2-methyl-2H-tetrazol-5-yl)methyl)-3-ethyl-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / CH₂Cl₂

2: H₂ / Pd/C / 1-methyl-pyrrolidin-2-one

3: TBAI / 1-methyl-pyrrolidin-2-one / 80 °C

4: 74 percent / DIEA

5: 65 percent / NaN₃; NH₄Cl / dimethylformamide

6: MeOH / tetrahydrofuran

With pyridine; methanol; sodium azide; hydrogen; tetra-(n-butyl)ammonium iodide; ammonium chloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.01.112

Reference yield:

: C₁₂H₁₅F₃N₂O₅S

: 871834-72-9
(3S)-1-((S)-(3,5-bis(trifluoromethyl)phenyl)(2-methyl-2H-tetrazol-5-yl)methyl)-3-ethyl-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C / 1-methyl-pyrrolidin-2-one

2: TBAI / 1-methyl-pyrrolidin-2-one / 80 °C

3: 74 percent / DIEA

4: 65 percent / NaN₃; NH₄Cl / dimethylformamide

5: MeOH / tetrahydrofuran

With methanol; sodium azide; hydrogen; tetra-(n-butyl)ammonium iodide; ammonium chloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.01.112