S-[2-[(2-ethylphenyl)amino]-2-oxoethyl] [2-[(2S)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]hydrazinyl]methanethioate

Base Information

• Chemical Name: S-[2-[(2-ethylphenyl)amino]-2-oxoethyl] [2-[(2S)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]hydrazinyl]methanethioate
• CAS No.: 958772-66-2
• Molecular Formula: C₂₇H₃₃N₅O₅S
• Molecular Weight: 539.656

Synonyms:S-[2-[(2-ethylphenyl)amino]-2-oxoethyl] [2-[(2S)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]hydrazinyl]methanethioate

Chemical Property of S-[2-[(2-ethylphenyl)amino]-2-oxoethyl] [2-[(2S)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]hydrazinyl]methanethioate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

SID26681509 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: SID 26681509 is a small molecule cathespin L inhibitor.

Technology Process of S-[2-[(2-ethylphenyl)amino]-2-oxoethyl] [2-[(2S)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]hydrazinyl]methanethioate

There total 3 articles about S-[2-[(2-ethylphenyl)amino]-2-oxoethyl] [2-[(2S)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]hydrazinyl]methanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc(L)-tryptophan hydrazide (132685-99-5) + 2-bromo-N-(2'-ethylphenyl)acetamide (895854-04-3) + carbon oxide sulfide (463-58-1) → S-[2-[(2-ethylphenyl)amino]-2-oxoethyl] [2-[(2S)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]hydrazinyl]methanethioate (958772-66-2)

Guidance literature:

Boc(L)-tryptophan hydrazide; carbon oxide sulfide; With potassium hydroxide; In ethanol; at 23 ℃; for 15h;

2-bromo-N-(2'-ethylphenyl)acetamide; In ethanol;

DOI:10.2174/138620710791054303

Reference yield:

C17H22N4O4S + C9H10BrNO → S-[2-[(2-ethylphenyl)amino]-2-oxoethyl] [2-[(2S)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]hydrazinyl]methanethioate (958772-66-2)

Guidance literature:

In ethanol; at 23 ℃; for 1h;

DOI:10.1016/j.bmcl.2008.04.065

Reference yield:

2-bromo-N-(2'-ethylphenyl)acetamide (895854-04-3) + C17H22N4O4S → S-[2-[(2-ethylphenyl)amino]-2-oxoethyl] [2-[(2S)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]hydrazinyl]methanethioate (958772-66-2)

Guidance literature:

at 23 ℃; for 0.333333h;

DOI:10.1016/j.bmcl.2007.10.107

upstream raw materials:

2-bromo-N-(2'-ethylphenyl)acetamide

Boc(L)-tryptophan hydrazide

carbon oxide sulfide

Downstream raw materials:

C₂₂H₂₅N₅O₃S

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