{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-acetic acid

Base Information

Chemical Name:{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-acetic acid
CAS No.:1266116-26-0
Molecular Formula:C₂₃H₃₁NO₃
Molecular Weight:369.504
Hs Code.:

Synonyms:{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-acetic acid

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Chemical Property of {[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-acetic acid

Chemical Property:

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Technology Process of {[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-acetic acid

There total 10 articles about {[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1266116-25-9
{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-acetic acid ethyl ester

: 1266116-26-0
{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-acetic acid

Guidance literature:: {[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-acetic acid ethyl ester; With water; lithium hydroxide; In methanol; at 20 - 50 ℃; for 5h;

With hydrogenchloride; In methanol; water; pH=6;

Reference yield:

: 937-05-3
cis-4-tert-butyl-1-cyclohexanol

: 1266116-26-0
{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 26 h / 0 - 30 °C

3.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C

3.3: pH 6

4.1: triethylamine; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

5.1: water; lithium hydroxide / methanol / 5 h / 20 - 50 °C

5.2: pH 6

With n-butyllithium; di-isopropyl azodicarboxylate; water; sodium tris(acetoxy)borohydride; triethylamine; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 15231-91-1
6-bromo-naphthalen-2-ol

: 1266116-26-0
{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / butanone; tert-butyl alcohol / 0.17 h / 110 °C

1.2: 15 h / 110 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C

2.3: pH 6

3.1: triethylamine; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

4.1: water; lithium hydroxide / methanol / 5 h / 20 - 50 °C

4.2: pH 6

With n-butyllithium; water; sodium tris(acetoxy)borohydride; caesium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; butanone; tert-butyl alcohol;