ethyl 3-[4-(6-acetoxy-7-t-butyl-2-methylchroman-2-ylmethoxy)phenyl]-2-chloropropionate

Base Information

• Chemical Name: ethyl 3-[4-(6-acetoxy-7-t-butyl-2-methylchroman-2-ylmethoxy)phenyl]-2-chloropropionate
• CAS No.: 97322-74-2
• Molecular Formula: C₂₈H₃₅ClO₆
• Molecular Weight: 503.035
• Mol file: 97322-74-2.mol

Synonyms:ethyl 3-[4-(6-acetoxy-7-t-butyl-2-methylchroman-2-ylmethoxy)phenyl]-2-chloropropionate

Chemical Property of ethyl 3-[4-(6-acetoxy-7-t-butyl-2-methylchroman-2-ylmethoxy)phenyl]-2-chloropropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-[4-(6-acetoxy-7-t-butyl-2-methylchroman-2-ylmethoxy)phenyl]-2-chloropropionate

There total 6 articles about ethyl 3-[4-(6-acetoxy-7-t-butyl-2-methylchroman-2-ylmethoxy)phenyl]-2-chloropropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-tert-Butyl-2-hydroxymethyl-2-methyl-chroman-6-ol → ethyl 3-[4-(6-acetoxy-7-t-butyl-2-methylchroman-2-ylmethoxy)phenyl]-2-chloropropionate (97322-74-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, 2.) benzene

2: 1.) NaH / 1.) DMSO, benzene

3: AcOH, 10percent H₂SO₄

4: pyridine

5: H₂ / 10percent Pd-C / methanol; benzene

6: 1.) aq. NaNO₂, conc. HCl, 2.) Cu₂O / 1.) acetone

With pyridine; copper(I) oxide; hydrogenchloride; sulfuric acid; hydrogen; sodium hydride; acetic acid; sodium nitrite; palladium on activated charcoal; In methanol; benzene;

DOI:10.1021/jm00122a022

Reference yield:

(7-tert-Butyl-6-methoxymethoxy-2-methyl-chroman-2-yl)-methanol (199339-73-6) → ethyl 3-[4-(6-acetoxy-7-t-butyl-2-methylchroman-2-ylmethoxy)phenyl]-2-chloropropionate (97322-74-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) NaH / 1.) DMSO, benzene

2: AcOH, 10percent H₂SO₄

3: pyridine

4: H₂ / 10percent Pd-C / methanol; benzene

5: 1.) aq. NaNO₂, conc. HCl, 2.) Cu₂O / 1.) acetone

With pyridine; copper(I) oxide; hydrogenchloride; sulfuric acid; hydrogen; sodium hydride; acetic acid; sodium nitrite; palladium on activated charcoal; In methanol; benzene;

DOI:10.1021/jm00122a022

Reference yield:

7-tert-Butyl-2-methyl-2-(4-nitro-phenoxymethyl)-chroman-6-ol → ethyl 3-[4-(6-acetoxy-7-t-butyl-2-methylchroman-2-ylmethoxy)phenyl]-2-chloropropionate (97322-74-2)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine

2: H₂ / 10percent Pd-C / methanol; benzene

3: 1.) aq. NaNO₂, conc. HCl, 2.) Cu₂O / 1.) acetone

With pyridine; copper(I) oxide; hydrogenchloride; hydrogen; sodium nitrite; palladium on activated charcoal; In methanol; benzene;

DOI:10.1021/jm00122a022

upstream raw materials:

(7-tert-Butyl-6-methoxymethoxy-2-methyl-chroman-2-yl)-methanol

Downstream raw materials:

5-[4-(7-t-Butyl-6-hydroxy-2-methylchroman-2-yl-methoxy)benzyl ]thiazolidine-2,4-dione