(S)-5-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-hydroxy-5-oxo-pentanoic acid ((S)-1-phenyl-ethyl)-amide

Base Information

Chemical Name:(S)-5-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-hydroxy-5-oxo-pentanoic acid ((S)-1-phenyl-ethyl)-amide
CAS No.:223437-38-5
Molecular Formula:C₂₃H₂₆N₂O₅
Molecular Weight:410.47
Hs Code.:

Synonyms:(S)-5-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-hydroxy-5-oxo-pentanoic acid ((S)-1-phenyl-ethyl)-amide

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Chemical Property of (S)-5-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-hydroxy-5-oxo-pentanoic acid ((S)-1-phenyl-ethyl)-amide

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Technology Process of (S)-5-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-hydroxy-5-oxo-pentanoic acid ((S)-1-phenyl-ethyl)-amide

There total 10 articles about (S)-5-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-hydroxy-5-oxo-pentanoic acid ((S)-1-phenyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 196491-68-6
3-[dimethyl(phenyl)silyl]glutaric anhydride

: 223437-38-5
(S)-5-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-hydroxy-5-oxo-pentanoic acid ((S)-1-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / BuLi, DMPU / tetrahydrofuran; hexane / 1.) -35 deg C, 10 min, 2.) -78 deg C, 1 h

2: Et₃N / tetrahydrofuran / 1 h / 0 °C

3: DMAP / tetrahydrofuran / Ambient temperature

4: 93 percent / H₂ / 10percent Pd/C / ethyl acetate / 48 h

5: peracetic acid, KBr, NaOAc / acetic acid / 24 h / Ambient temperature

6: DMAP, DCCI / CH₂Cl₂ / Ambient temperature

With peracetic acid; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; hydrogen; sodium acetate; triethylamine; dicyclohexyl-carbodiimide; potassium bromide; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; acetic acid; ethyl acetate;
DOI:10.1039/a808838a

Reference yield:

: 90719-32-7
(S)-4-Benzyl-2-oxazolidinone

: 223437-38-5
(S)-5-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-hydroxy-5-oxo-pentanoic acid ((S)-1-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / BuLi, DMPU / tetrahydrofuran; hexane / 1.) -35 deg C, 10 min, 2.) -78 deg C, 1 h

2: Et₃N / tetrahydrofuran / 1 h / 0 °C

3: DMAP / tetrahydrofuran / Ambient temperature

4: 93 percent / H₂ / 10percent Pd/C / ethyl acetate / 48 h

5: peracetic acid, KBr, NaOAc / acetic acid / 24 h / Ambient temperature

6: DMAP, DCCI / CH₂Cl₂ / Ambient temperature

With peracetic acid; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; hydrogen; sodium acetate; triethylamine; dicyclohexyl-carbodiimide; potassium bromide; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; acetic acid; ethyl acetate;
DOI:10.1039/a808838a

Reference yield:

: C₂₈H₃₅NO₆Si

: 223437-38-5
(S)-5-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-hydroxy-5-oxo-pentanoic acid ((S)-1-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: DMAP / tetrahydrofuran / Ambient temperature

2: 93 percent / H₂ / 10percent Pd/C / ethyl acetate / 48 h

3: peracetic acid, KBr, NaOAc / acetic acid / 24 h / Ambient temperature

4: DMAP, DCCI / CH₂Cl₂ / Ambient temperature

With peracetic acid; dmap; hydrogen; sodium acetate; dicyclohexyl-carbodiimide; potassium bromide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid; ethyl acetate;
DOI:10.1039/a808838a