(R)-2-cyclopropyl-N-hydroxy-2-[4-(2-methylamino-pyrimidin-5-yl)-phenyl]-propionamidine

Base Information

Chemical Name:(R)-2-cyclopropyl-N-hydroxy-2-[4-(2-methylamino-pyrimidin-5-yl)-phenyl]-propionamidine
CAS No.:1360552-11-9
Molecular Formula:C₁₇H₂₁N₅O
Molecular Weight:311.387
Hs Code.:

Synonyms:(R)-2-cyclopropyl-N-hydroxy-2-[4-(2-methylamino-pyrimidin-5-yl)-phenyl]-propionamidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-cyclopropyl-N-hydroxy-2-[4-(2-methylamino-pyrimidin-5-yl)-phenyl]-propionamidine

Chemical Property:

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Technology Process of (R)-2-cyclopropyl-N-hydroxy-2-[4-(2-methylamino-pyrimidin-5-yl)-phenyl]-propionamidine

There total 5 articles about (R)-2-cyclopropyl-N-hydroxy-2-[4-(2-methylamino-pyrimidin-5-yl)-phenyl]-propionamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360552-10-8
C₁₇H₁₈N₄

: 1360552-11-9
(R)-2-cyclopropyl-N-hydroxy-2-[4-(2-methylamino-pyrimidin-5-yl)-phenyl]-propionamidine

Guidance literature:: With hydroxylamine; In ethanol; water; at 85 ℃; for 72h;

Reference yield:

: 6952-89-2
(4-bromophenyl)(cyclopropyl)methanone

: 1360552-11-9
(R)-2-cyclopropyl-N-hydroxy-2-[4-(2-methylamino-pyrimidin-5-yl)-phenyl]-propionamidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran; diethyl ether / 2.16 h / -78 - 20 °C

2.1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / -78 °C

2.2: 2 h / -78 - 20 °C

3.1: carbon dioxide / ethanol / Resolution of racemate

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; hexamethyldistannane / toluene / 1 h / 115 °C / Inert atmosphere; Sealed tube; Microwave irradiation

4.2: 115 °C / Sealed tube

5.1: water; hydroxylamine / ethanol / 72 h / 85 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon dioxide; boron trifluoride diethyl etherate; water; hydroxylamine; hexamethyldistannane; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; toluene;

Reference yield:

: 56041-75-9
1-(4-bromophenyl)-1-cyclopropylethan-1-ol

: 1360552-11-9
(R)-2-cyclopropyl-N-hydroxy-2-[4-(2-methylamino-pyrimidin-5-yl)-phenyl]-propionamidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / -78 °C

1.2: 2 h / -78 - 20 °C

2.1: carbon dioxide / ethanol / Resolution of racemate

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; hexamethyldistannane / toluene / 1 h / 115 °C / Inert atmosphere; Sealed tube; Microwave irradiation

3.2: 115 °C / Sealed tube

4.1: water; hydroxylamine / ethanol / 72 h / 85 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon dioxide; boron trifluoride diethyl etherate; water; hydroxylamine; hexamethyldistannane; In ethanol; dichloromethane; toluene;