N-(2-{3-[2-fluoro-3-(trifluoromethyl)phenyl]-8-methoxy-4-oxocinnolin-1(4H)-yl}ethyl)methanesulphonamide

Base Information

Chemical Name:N-(2-{3-[2-fluoro-3-(trifluoromethyl)phenyl]-8-methoxy-4-oxocinnolin-1(4H)-yl}ethyl)methanesulphonamide
CAS No.:1246921-14-1
Molecular Formula:C₁₉H₁₇F₄N₃O₄S
Molecular Weight:459.421
Hs Code.:

Synonyms:N-(2-{3-[2-fluoro-3-(trifluoromethyl)phenyl]-8-methoxy-4-oxocinnolin-1(4H)-yl}ethyl)methanesulphonamide

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Chemical Property of N-(2-{3-[2-fluoro-3-(trifluoromethyl)phenyl]-8-methoxy-4-oxocinnolin-1(4H)-yl}ethyl)methanesulphonamide

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Technology Process of N-(2-{3-[2-fluoro-3-(trifluoromethyl)phenyl]-8-methoxy-4-oxocinnolin-1(4H)-yl}ethyl)methanesulphonamide

There total 9 articles about N-(2-{3-[2-fluoro-3-(trifluoromethyl)phenyl]-8-methoxy-4-oxocinnolin-1(4H)-yl}ethyl)methanesulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2-fluoro-3-(trifluoromethyl)phenyl)boronic acid

: 1246921-08-3
N-[2-(3-Iodo-8-methoxy-4-oxocinnolin-1(4H)-yl)ethyl]methanesulphonamide

: 1246921-14-1
N-(2-{3-[2-fluoro-3-(trifluoromethyl)phenyl]-8-methoxy-4-oxocinnolin-1(4H)-yl}ethyl)methanesulphonamide

Guidance literature:: With sodium carbonate; In methanol; toluene; at 65 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 39061-72-8
2-acetyl-5-chloroaniline

: 1246921-14-1
N-(2-{3-[2-fluoro-3-(trifluoromethyl)phenyl]-8-methoxy-4-oxocinnolin-1(4H)-yl}ethyl)methanesulphonamide

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride; sodium nitrite / water / 0 - 20 °C

2: pyridine; iodine / dichloromethane / 20 °C

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.75 h / 5 - 20 °C

4: hydrazine hydrate / methanol / 3 h / 65 °C

5: triethylamine / dichloromethane / 48 h / 20 °C

6: sodium carbonate / toluene; methanol / 1.5 h / 65 °C / Inert atmosphere

With pyridine; hydrogenchloride; iodine; sodium carbonate; hydrazine hydrate; triethylamine; triphenylphosphine; sodium nitrite; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water; toluene;

Reference yield:

: 89-77-0
2-Amino-4-chlorobenzoic acid

: 1246921-14-1
N-(2-{3-[2-fluoro-3-(trifluoromethyl)phenyl]-8-methoxy-4-oxocinnolin-1(4H)-yl}ethyl)methanesulphonamide

Guidance literature:: Multi-step reaction with 10 steps

1: triethylamine / 1,4-dioxane; water / 48 h / 20 °C

2: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 20 °C

3: methylmagnesium bromide / tetrahydrofuran / -40 - 20 °C

4: trifluoroacetic acid / dichloromethane / 20 °C

5: hydrogenchloride; sodium nitrite / water / 0 - 20 °C

6: pyridine; iodine / dichloromethane / 20 °C

7: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.75 h / 5 - 20 °C

8: hydrazine hydrate / methanol / 3 h / 65 °C

9: triethylamine / dichloromethane / 48 h / 20 °C

10: sodium carbonate / toluene; methanol / 1.5 h / 65 °C / Inert atmosphere

With pyridine; hydrogenchloride; methylmagnesium bromide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; iodine; sodium carbonate; hydrazine hydrate; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium nitrite; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; toluene;