(4S)-(S)-1-(benzyloxy)-4-methyl-1-oxopentan-2-yl 4-((tert-butoxycarbonyl)amino)-3-hydroxy-2,2,6-trimethylheptanoate

Base Information

Chemical Name:(4S)-(S)-1-(benzyloxy)-4-methyl-1-oxopentan-2-yl 4-((tert-butoxycarbonyl)amino)-3-hydroxy-2,2,6-trimethylheptanoate
CAS No.:1599436-52-8
Molecular Formula:C₂₈H₄₅NO₇
Molecular Weight:507.668
Hs Code.:

Synonyms:(4S)-(S)-1-(benzyloxy)-4-methyl-1-oxopentan-2-yl 4-((tert-butoxycarbonyl)amino)-3-hydroxy-2,2,6-trimethylheptanoate

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Chemical Property of (4S)-(S)-1-(benzyloxy)-4-methyl-1-oxopentan-2-yl 4-((tert-butoxycarbonyl)amino)-3-hydroxy-2,2,6-trimethylheptanoate

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Technology Process of (4S)-(S)-1-(benzyloxy)-4-methyl-1-oxopentan-2-yl 4-((tert-butoxycarbonyl)amino)-3-hydroxy-2,2,6-trimethylheptanoate

There total 4 articles about (4S)-(S)-1-(benzyloxy)-4-methyl-1-oxopentan-2-yl 4-((tert-butoxycarbonyl)amino)-3-hydroxy-2,2,6-trimethylheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1599436-51-7
(4S)-tert-butyl 5-(1-(((S)-1-(benzyloxy)-4-methyl-1-oxopentan-2-yl)oxy)-2-methyl-1-oxopropan-2-yl)-4-isobutyl-2,2-dimethyloxazolidine-3-carboxylate

: 1599436-52-8
(4S)-(S)-1-(benzyloxy)-4-methyl-1-oxopentan-2-yl 4-((tert-butoxycarbonyl)amino)-3-hydroxy-2,2,6-trimethylheptanoate

Guidance literature:: With hydrogenchloride; In water; ethyl acetate; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/ol500484f

Reference yield:

: 1599436-56-2
C₁₈H₃₃NO₄

: 1599436-52-8
(4S)-(S)-1-(benzyloxy)-4-methyl-1-oxopentan-2-yl 4-((tert-butoxycarbonyl)amino)-3-hydroxy-2,2,6-trimethylheptanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium dihydrogen phosphate monohydrate; sodium chlorite; 2-methyl-but-2-ene / tert-butyl alcohol; water / 18 h / 20 °C / Inert atmosphere

2.1: dmap; triethylamine; 2-methyl-6-nitrobenzoic anhydride / 0.25 h / 20 °C / Inert atmosphere

2.2: 40 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / ethyl acetate; water / 18 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; 2-methyl-6-nitrobenzoic anhydride; triethylamine; In water; ethyl acetate; tert-butyl alcohol;
DOI:10.1021/ol500484f

Reference yield:

: 1599436-49-3
(4S)-tert-butyl 4-isobutyl-2,2-dimethyl-5-(2-methylbut-3-en-2-yl)oxazolidine-3-carboxylate

: 1599436-52-8
(4S)-(S)-1-(benzyloxy)-4-methyl-1-oxopentan-2-yl 4-((tert-butoxycarbonyl)amino)-3-hydroxy-2,2,6-trimethylheptanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; dichloromethane / 18 h / 20 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: sodium dihydrogen phosphate monohydrate; sodium chlorite; 2-methyl-but-2-ene / tert-butyl alcohol; water / 18 h / 20 °C / Inert atmosphere

3.1: dmap; triethylamine; 2-methyl-6-nitrobenzoic anhydride / 0.25 h / 20 °C / Inert atmosphere

3.2: 40 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride / ethyl acetate; water / 18 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; sodium chlorite; osmium(VIII) oxide; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; 2-methyl-6-nitrobenzoic anhydride; 4-methylmorpholine N-oxide; triethylamine; In dichloromethane; water; ethyl acetate; tert-butyl alcohol;
DOI:10.1021/ol500484f