(S)-<2,2-Bis(methylthio)-1-cyclobutyl>methanol t-butyldiphenylsilyl ether

Base Information

• Chemical Name: (S)-<2,2-Bis(methylthio)-1-cyclobutyl>methanol t-butyldiphenylsilyl ether
• CAS No.: 135253-28-0
• Molecular Formula: C₂₃H₃₂OS₂Si
• Molecular Weight: 416.724
• Mol file: 135253-28-0.mol

Synonyms:(S)-<2,2-Bis(methylthio)-1-cyclobutyl>methanol t-butyldiphenylsilyl ether

Chemical Property of (S)-<2,2-Bis(methylthio)-1-cyclobutyl>methanol t-butyldiphenylsilyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-<2,2-Bis(methylthio)-1-cyclobutyl>methanol t-butyldiphenylsilyl ether

There total 3 articles about (S)-<2,2-Bis(methylthio)-1-cyclobutyl>methanol t-butyldiphenylsilyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methyl (S)-2,2-bis(methylthio)cyclobutane-1-carboxylate (135356-00-2) → (S)-<2,2-Bis(methylthio)-1-cyclobutyl>methanol t-butyldiphenylsilyl ether (135253-28-0)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / 0.08 h / 0 °C

2: NEt₃, 4-dimethylaminopyridine / CH₂Cl₂

With dmap; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1246/bcsj.64.1471

Reference yield:

(S)-3-<2,2-Bis(methylthio)-1-cyclobutylcarbonyl>-1,3-oxazolidin-2-one (135253-27-9) → (S)-<2,2-Bis(methylthio)-1-cyclobutyl>methanol t-butyldiphenylsilyl ether (135253-28-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) Mg, CCl₄ / 2) THF

2: LiAlH₄ / tetrahydrofuran / 0.08 h / 0 °C

3: NEt₃, 4-dimethylaminopyridine / CH₂Cl₂

With tetrachloromethane; dmap; lithium aluminium tetrahydride; magnesium; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1246/bcsj.64.1471

Reference yield:

(S)-<2,2-Bis(methylthio)-1-cyclobutyl>methanol (135356-01-3) + tert-butylchlorodiphenylsilane (58479-61-1) → (S)-<2,2-Bis(methylthio)-1-cyclobutyl>methanol t-butyldiphenylsilyl ether (135253-28-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; Yield given;

DOI:10.1246/bcsj.64.1471

upstream raw materials:

(S)-<2,2-Bis(methylthio)-1-cyclobutyl>methanol

tert-butylchlorodiphenylsilane

Methyl (S)-2,2-bis(methylthio)cyclobutane-1-carboxylate

(S)-3-<2,2-Bis(methylthio)-1-cyclobutylcarbonyl>-1,3-oxazolidin-2-one

Downstream raw materials:

(S)-2-(((tert-butyldiphenylsilyl)oxy)methyl)cyclobutanone

(1R, 2S)-grandisol

1-{(1R,2R)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2-methyl-cyclobutyl}-ethanol

tert-Butyl-[2-((1R,2S)-2-isopropenyl-1-methyl-cyclobutyl)-ethoxy]-diphenyl-silane