(1S,2S)-trans-1-benzylaminoethyl-1,2-dimethyl-1,2-dihydronaphthalene

Base Information

• Chemical Name: (1S,2S)-trans-1-benzylaminoethyl-1,2-dimethyl-1,2-dihydronaphthalene
• CAS No.: 161187-41-3
• Molecular Formula: C₂₁H₂₅N
• Molecular Weight: 291.436
• Mol file: 161187-41-3.mol

Synonyms:(1S,2S)-trans-1-benzylaminoethyl-1,2-dimethyl-1,2-dihydronaphthalene

Chemical Property of (1S,2S)-trans-1-benzylaminoethyl-1,2-dimethyl-1,2-dihydronaphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S)-trans-1-benzylaminoethyl-1,2-dimethyl-1,2-dihydronaphthalene

There total 4 articles about (1S,2S)-trans-1-benzylaminoethyl-1,2-dimethyl-1,2-dihydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzylamine hydrochloride (3287-99-8,39110-74-2,108321-65-9) + ((1S,2S)-1,2-Dimethyl-1,2-dihydro-naphthalen-1-yl)-acetaldehyde (161187-37-7) → (1S,2S)-trans-1-benzylaminoethyl-1,2-dimethyl-1,2-dihydronaphthalene (161187-41-3)

Guidance literature:

With sodium cyanoborohydride; In methanol; Ambient temperature;

DOI:10.1016/0040-4039(94)88402-1

Reference yield:

(4R)-2-(1-Naphthyl)-4-phenyl-1,3-oxazolidine (252864-72-5) → (1S,2S)-trans-1-benzylaminoethyl-1,2-dimethyl-1,2-dihydronaphthalene (161187-41-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 3.) 3N HCl / 1.) -78 deg C to 25 deg C, 2.) 25 deg C

2: 91 percent / NaHMDS / tetrahydrofuran / -78 °C

3: 72 percent / aq oxalic acid / Heating

4: 92 percent / sodium cyanoborohydride / methanol / Ambient temperature

With hydrogenchloride; sodium hexamethyldisilazane; oxalic acid; sodium cyanoborohydride; In tetrahydrofuran; methanol;

DOI:10.1016/0040-4039(94)88402-1

Reference yield:

(1S,2S)-1,2-dimethyl-1,2-dihydronaphthalenecarboxaldehyde (157381-06-1) → (1S,2S)-trans-1-benzylaminoethyl-1,2-dimethyl-1,2-dihydronaphthalene (161187-41-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / NaHMDS / tetrahydrofuran / -78 °C

2: 72 percent / aq oxalic acid / Heating

3: 92 percent / sodium cyanoborohydride / methanol / Ambient temperature

With sodium hexamethyldisilazane; oxalic acid; sodium cyanoborohydride; In tetrahydrofuran; methanol;

DOI:10.1016/0040-4039(94)88402-1

upstream raw materials:

benzylamine hydrochloride

((1S,2S)-1,2-Dimethyl-1,2-dihydro-naphthalen-1-yl)-acetaldehyde

(4R)-2-(1-Naphthyl)-4-phenyl-1,3-oxazolidine

(1S,2S)-1,2-dimethyl-1,2-dihydronaphthalenecarboxaldehyde