ethyl 2-[3-[1-(4-fluorobenzoyl)-4-hydroxypiperidin-4-yl]phenoxy]-2-methylpropanoate

Base Information

Chemical Name:ethyl 2-[3-[1-(4-fluorobenzoyl)-4-hydroxypiperidin-4-yl]phenoxy]-2-methylpropanoate
CAS No.:325808-45-5
Molecular Formula:C₂₄H₂₈FNO₅
Molecular Weight:429.488
Hs Code.:

Synonyms:ethyl 2-[3-[1-(4-fluorobenzoyl)-4-hydroxypiperidin-4-yl]phenoxy]-2-methylpropanoate

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Chemical Property of ethyl 2-[3-[1-(4-fluorobenzoyl)-4-hydroxypiperidin-4-yl]phenoxy]-2-methylpropanoate

Chemical Property:

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Technology Process of ethyl 2-[3-[1-(4-fluorobenzoyl)-4-hydroxypiperidin-4-yl]phenoxy]-2-methylpropanoate

There total 5 articles about ethyl 2-[3-[1-(4-fluorobenzoyl)-4-hydroxypiperidin-4-yl]phenoxy]-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 600-00-0
ethyl 2-bromoisobutyrate

: 325808-16-0
1-(4-fluorobenzoyl)-4-hydroxy-4-(3-hydroxyphenyl)piperidine

: 325808-45-5
ethyl 2-[3-[1-(4-fluorobenzoyl)-4-hydroxypiperidin-4-yl]phenoxy]-2-methylpropanoate

Guidance literature:: With potassium carbonate; at 100 ℃; for 14h;
DOI:10.1248/cpb.48.1978

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 325808-45-5
ethyl 2-[3-[1-(4-fluorobenzoyl)-4-hydroxypiperidin-4-yl]phenoxy]-2-methylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / tetrahydrofuran / 2 h / Heating

2: 77 percent / H₂ / Pd(OH)2 / methanol / 6 h / 20 °C / 3040 Torr

3: 87 percent / Et₃N / tetrahydrofuran / 2 h / 20 °C

4: 100 percent / K₂CO₃ / 14 h / 100 °C

With hydrogen; potassium carbonate; triethylamine; palladium dihydroxide; In tetrahydrofuran; methanol;
DOI:10.1248/cpb.48.1978

Reference yield:

: 36281-96-6
<3-(benzyloxy)phenyl>magnesium bromide

: 325808-45-5
ethyl 2-[3-[1-(4-fluorobenzoyl)-4-hydroxypiperidin-4-yl]phenoxy]-2-methylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / tetrahydrofuran / 2 h / Heating

2: 77 percent / H₂ / Pd(OH)2 / methanol / 6 h / 20 °C / 3040 Torr

3: 87 percent / Et₃N / tetrahydrofuran / 2 h / 20 °C

4: 100 percent / K₂CO₃ / 14 h / 100 °C

With hydrogen; potassium carbonate; triethylamine; palladium dihydroxide; In tetrahydrofuran; methanol;
DOI:10.1248/cpb.48.1978