N-(N'-benzyl-N'-tert-butoxycarbonyl-6-aminohexyl)-N-tert-butoxycarbonyl-6-aminohexanoic acid

Base Information

• Chemical Name: N-(N'-benzyl-N'-tert-butoxycarbonyl-6-aminohexyl)-N-tert-butoxycarbonyl-6-aminohexanoic acid
• CAS No.: 213772-98-6
• Molecular Formula: C₂₉H₄₈N₂O₆
• Molecular Weight: 520.71
• Mol file: 213772-98-6.mol

Synonyms:N-(N'-benzyl-N'-tert-butoxycarbonyl-6-aminohexyl)-N-tert-butoxycarbonyl-6-aminohexanoic acid

Chemical Property of N-(N'-benzyl-N'-tert-butoxycarbonyl-6-aminohexyl)-N-tert-butoxycarbonyl-6-aminohexanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(N'-benzyl-N'-tert-butoxycarbonyl-6-aminohexyl)-N-tert-butoxycarbonyl-6-aminohexanoic acid

There total 9 articles about N-(N'-benzyl-N'-tert-butoxycarbonyl-6-aminohexyl)-N-tert-butoxycarbonyl-6-aminohexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

[6-(benzyl-tert-butoxycarbonyl-amino)-hexyl]-(6-hydroxy-hexyl)-carbamic acid tert-butyl ester (213772-78-2) → N-(N'-benzyl-N'-tert-butoxycarbonyl-6-aminohexyl)-N-tert-butoxycarbonyl-6-aminohexanoic acid (213772-98-6)

Guidance literature:

With dipyridinium dichromate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/S0968-0896(00)00055-9

Reference yield:

6-amino-1-hexanol (4048-33-3) → N-(N'-benzyl-N'-tert-butoxycarbonyl-6-aminohexyl)-N-tert-butoxycarbonyl-6-aminohexanoic acid (213772-98-6)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 6 h / 100 °C

2: CH₂Cl₂ / 3 h / 20 °C

3: aq. NaHCO₃; NaOCl; KBr / TEMPO; tricaprylylmethylammonium chloride / CH₂Cl₂ / 5 h / 0 °C / pH 8

With sodium hypochlorite; sodium hydrogencarbonate; potassium carbonate; potassium bromide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; Aliquat 336; In dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Substitution / 3: Oxidation;

DOI:10.1080/15257770008035031

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → N-(N'-benzyl-N'-tert-butoxycarbonyl-6-aminohexyl)-N-tert-butoxycarbonyl-6-aminohexanoic acid (213772-98-6)

Guidance literature:

Multi-step reaction with 5 steps

1: CH₂Cl₂ / 3 h / 20 °C

2: Et₃N / diethyl ether

3: K₂CO₃ / dimethylformamide / 6 h / 100 °C

4: CH₂Cl₂ / 3 h / 20 °C

5: aq. NaHCO₃; NaOCl; KBr / TEMPO; tricaprylylmethylammonium chloride / CH₂Cl₂ / 5 h / 0 °C / pH 8

With sodium hypochlorite; sodium hydrogencarbonate; potassium carbonate; triethylamine; potassium bromide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; Aliquat 336; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Tosylation / 3: Substitution / 4: Substitution / 5: Oxidation;

DOI:10.1080/15257770008035031

upstream raw materials:

[6-(benzyl-tert-butoxycarbonyl-amino)-hexyl]-(6-hydroxy-hexyl)-carbamic acid tert-butyl ester

6-amino-1-hexanol

di-tert-butyl dicarbonate

benzaldehyde

Downstream raw materials:

[5-(benzyl-{3-[benzyl-(6-{[6-(benzyl-tert-butoxycarbonyl-amino)-hexyl]-tert-butoxycarbonyl-amino}-hexanoyl)-amino]-2-oxo-propyl}-carbamoyl)-pentyl]-[6-(benzyl-tert-butoxycarbonyl-amino)-hexyl]-carbamic acid tert-butyl ester