5-(Hydroxymethyl)-2-phenylpyrimidine

Base Information

• Chemical Name: 5-(Hydroxymethyl)-2-phenylpyrimidine
• CAS No.: 886531-62-0
• Molecular Formula: C11H10N2O
• Molecular Weight: 186.213
• Hs Code.: 2933599590
• Mol file: 886531-62-0.mol

Synonyms:(2-Phenylpyrimidin-5-yl)methanol;

Chemical Property of 5-(Hydroxymethyl)-2-phenylpyrimidine

Chemical Property:

• Vapor Pressure: 0.00348mmHg at 25°C
• Melting Point: 111-113 °C
• Refractive Index: 1.606
• Boiling Point: 269.9 °C at 760 mmHg
• Flash Point: 117 °C
• Density: 1.201 g/cm³

Purity/Quality:

98%Min ^*data from raw suppliers

(2-phenylpyrimidin-5-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(Hydroxymethyl)-2-phenylpyrimidine

There total 3 articles about 5-(Hydroxymethyl)-2-phenylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

→ (2-phenylpyrimidin-5-yl)methanol (886531-62-0)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 2h;

Reference yield: 65.0%

2-phenylpyrimidine-5-carbaldehyde (130161-46-5) → (2-phenylpyrimidin-5-yl)methanol (886531-62-0)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield: 44.0%

2-chloro-5-hydroxymethyl-pyrimidine (1046816-75-4) + phenylboronic acid (98-80-6) → (2-phenylpyrimidin-5-yl)methanol (886531-62-0)

Guidance literature:

With palladium diacetate; anhydrous sodium carbonate; dicyclohexyl(2’,4’,6’-triisopropyl-[ 1,1’-bi-phenyl]-2-yl)phosphane; In 1,4-dioxane; water monomer; at 100 ℃; for 12h;

upstream raw materials:

2-phenylpyrimidine-5-carbaldehyde

2-chloro-5-hydroxymethyl-pyrimidine

phenylboronic acid

Downstream raw materials:

6-(methylsulfonyl)-2-(2-phenylpyrimidin-5-yl)-1H-benzimidazole

2-phenylpyrimidine-5-carbaldehyde

Refernces

• 1、 -. "cGAS ANTAGONIST COMPOUNDS". Paragraph 0217; 0238; 0249. . Retrieved 2017/11/06.