1-ethyl-6-fluoro-7-<3-(4-fluorophenyl)-5,6-dihydro-1(4H)pyridazinyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Base Information

• Chemical Name: 1-ethyl-6-fluoro-7-<3-(4-fluorophenyl)-5,6-dihydro-1(4H)pyridazinyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
• CAS No.: 120109-88-8
• Molecular Formula: C₂₂H₁₉F₂N₃O₃
• Molecular Weight: 411.408

Synonyms:1-ethyl-6-fluoro-7-<3-(4-fluorophenyl)-5,6-dihydro-1(4H)pyridazinyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Chemical Property of 1-ethyl-6-fluoro-7-<3-(4-fluorophenyl)-5,6-dihydro-1(4H)pyridazinyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Chemical Property:

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Technology Process of 1-ethyl-6-fluoro-7-<3-(4-fluorophenyl)-5,6-dihydro-1(4H)pyridazinyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

There total 3 articles about 1-ethyl-6-fluoro-7-<3-(4-fluorophenyl)-5,6-dihydro-1(4H)pyridazinyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

7-{N'-[4-Chloro-1-(4-fluoro-phenyl)-but-(E)-ylidene]-hydrazino}-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (120110-05-6) → 1-ethyl-6-fluoro-7-<3-(4-fluorophenyl)-5,6-dihydro-1(4H)pyridazinyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (120109-88-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 100 ℃; for 3h;

DOI:10.1002/jhet.5570250553

Reference yield:

6,7-difluoro-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (70032-25-6) → 1-ethyl-6-fluoro-7-<3-(4-fluorophenyl)-5,6-dihydro-1(4H)pyridazinyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (120109-88-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / N₂H₄*H₂O / pyridine / 1 h / 80 °C

2: 47 percent / ethanol / Heating

3: 46 percent / NaH / dimethylformamide / 3 h / 100 °C

With sodium hydride; hydrazine hydrate; In pyridine; ethanol; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570250553

Reference yield:

7-hydrazino-4-oxo-6-fluoro-1-ethyl-1,4-dihydro-3-quinolinecarboxylic acid (120109-97-9) → 1-ethyl-6-fluoro-7-<3-(4-fluorophenyl)-5,6-dihydro-1(4H)pyridazinyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (120109-88-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / ethanol / Heating

2: 46 percent / NaH / dimethylformamide / 3 h / 100 °C

With sodium hydride; In ethanol; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570250553

upstream raw materials:

7-{N'-[4-Chloro-1-(4-fluoro-phenyl)-but-(E)-ylidene]-hydrazino}-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

6,7-difluoro-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

7-hydrazino-4-oxo-6-fluoro-1-ethyl-1,4-dihydro-3-quinolinecarboxylic acid

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