2,2,2-trichloroethyl 6α-phenylacetoxypenicillanate

Base Information

• Chemical Name: 2,2,2-trichloroethyl 6α-phenylacetoxypenicillanate
• CAS No.: 67282-00-2
• Molecular Formula: C₁₈H₁₈Cl₃NO₅S
• Molecular Weight: 466.77
• Mol file: 67282-00-2.mol

Synonyms:2,2,2-trichloroethyl 6α-phenylacetoxypenicillanate

Chemical Property of 2,2,2-trichloroethyl 6α-phenylacetoxypenicillanate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-trichloroethyl 6α-phenylacetoxypenicillanate

There total 2 articles about 2,2,2-trichloroethyl 6α-phenylacetoxypenicillanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

phenylacetic acid (103-82-2) + (2S,5R)-6-Diazo-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 2,2,2-trichloro-ethyl ester (51056-24-7) → 2,2,2-trichloroethyl 6α-phenylacetoxypenicillanate (67282-00-2)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

6β-(nitroso-phenylacetyl-amino)-penicillanic acid 2,2,2-trichloro-ethyl ester (51056-23-6) → 2,2,2-trichloroethyl 6α-phenylacetoxypenicillanate (67282-00-2)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 4 h / Heating

2: 40 percent / BF₃*Et₂O / CH₂Cl₂ / 0.5 h / 20 °C

With boron trifluoride diethyl etherate; In dichloromethane;

upstream raw materials:

phenylacetic acid

(2S,5R)-6-Diazo-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 2,2,2-trichloro-ethyl ester

6β-(nitroso-phenylacetyl-amino)-penicillanic acid 2,2,2-trichloro-ethyl ester