Technology Process of (S)-(2-{3-[((3S,18S)-3-Cyclohexyl-2,5-dioxo-12-oxa-1,4-diaza-tricyclo[11.5.3.016,20]henicosa-13(21),14,16(20)-triene-18-carbonyl)-amino]-2-oxo-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester
There total 16 articles about (S)-(2-{3-[((3S,18S)-3-Cyclohexyl-2,5-dioxo-12-oxa-1,4-diaza-tricyclo[11.5.3.016,20]henicosa-13(21),14,16(20)-triene-18-carbonyl)-amino]-2-oxo-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Dess-Martin periodane;
In
dichloromethane;
at 20 ℃;
for 4h;
DOI:10.1021/jm050520a
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 66 percent / H2; acetic acid / Pd/C / 20 h / 20 °C / 3051.17 Torr
2.1: aq. NaOH / dioxane / 0.17 h / 0 °C
2.2: 89 percent / dioxane; H2O / 1 h / 0 - 20 °C
3.1: 95 percent / 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-methylmorpholine / dimethylformamide; CH2Cl2 / -20 °C
4.1: 98 percent / H2 / Pd/C / ethanol / 3 h / 20 °C
5.1: 80 percent / 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-methylmorpholine / dimethylformamide; CH2Cl2 / -20 °C
6.1: 100 percent / HCl / dioxane; ethyl acetate / 0.25 h / 20 °C
7.1: 80 percent / 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-methylmorpholine / dimethylformamide; CH2Cl2 / -20 °C
8.1: 88 percent / Dess-Martin periodinane / CH2Cl2 / 4 h / 20 °C
With
4-methyl-morpholine; hydrogenchloride; sodium hydroxide; hydrogen; Dess-Martin periodane; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one;
palladium on activated charcoal;
In
1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
8.1: Dess-Martin periodinane oxidation;
DOI:10.1021/jm050520a
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 95 percent / 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-methylmorpholine / dimethylformamide; CH2Cl2 / -20 °C
2: 98 percent / H2 / Pd/C / ethanol / 3 h / 20 °C
3: 80 percent / 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-methylmorpholine / dimethylformamide; CH2Cl2 / -20 °C
4: 100 percent / HCl / dioxane; ethyl acetate / 0.25 h / 20 °C
5: 80 percent / 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-methylmorpholine / dimethylformamide; CH2Cl2 / -20 °C
6: 88 percent / Dess-Martin periodinane / CH2Cl2 / 4 h / 20 °C
With
4-methyl-morpholine; hydrogenchloride; hydrogen; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one;
palladium on activated charcoal;
In
1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
6: Dess-Martin periodinane oxidation;
DOI:10.1021/jm050520a
![(S)-(2-{3-[((3S,18S)-3-Cyclohexyl-2,5-dioxo-12-oxa-1,4-diaza-tricyclo[11.5.3.0<sup>16,20</sup>]henicosa-13<sup>(21)</sup>,14,16<sup>(20)</sup>-triene-18-carbonyl)-amino]-2-hydroxy-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester](/Databaselist/images/loading.webp)
