(1S,2S)-[1-benzamido-2-methoxycyclohexane-1-carboxamido]-(S)-phenylalanine cyclohexylamide

Base Information

Chemical Name:(1S,2S)-[1-benzamido-2-methoxycyclohexane-1-carboxamido]-(S)-phenylalanine cyclohexylamide
CAS No.:345894-52-2
Molecular Formula:C₃₀H₃₉N₃O₄
Molecular Weight:505.657
Hs Code.:

Synonyms:(1S,2S)-[1-benzamido-2-methoxycyclohexane-1-carboxamido]-(S)-phenylalanine cyclohexylamide

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Chemical Property of (1S,2S)-[1-benzamido-2-methoxycyclohexane-1-carboxamido]-(S)-phenylalanine cyclohexylamide

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Technology Process of (1S,2S)-[1-benzamido-2-methoxycyclohexane-1-carboxamido]-(S)-phenylalanine cyclohexylamide

There total 9 articles about (1S,2S)-[1-benzamido-2-methoxycyclohexane-1-carboxamido]-(S)-phenylalanine cyclohexylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 17186-53-7,92698-80-1
L-phenylalanine cyclohexylamide

: trans-2-methoxycyclohexane-1-spiro-{4'[2'-phenyl-5'(4'H)oxazolone]}

: 345894-53-3
(1R,2R)-[1-benzamido-2-methoxycyclohexane-1-carboxamido]-(S)-phenylalanine cyclohexylamide

: 345894-52-2
(1S,2S)-[1-benzamido-2-methoxycyclohexane-1-carboxamido]-(S)-phenylalanine cyclohexylamide

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 90 ℃; for 48h;
DOI:10.1016/S0040-4020(01)00129-6

Reference yield:

: 24153-31-9
2-benzoylaminoacrylic acid methyl ester

: 345894-52-2
(1S,2S)-[1-benzamido-2-methoxycyclohexane-1-carboxamido]-(S)-phenylalanine cyclohexylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / toluene / 144 h / 85 °C

2: 99 percent / H₂ / Pd-C / methanol / 6 h / 25 °C

3: 93 percent / LiOH*H₂O / methanol; H₂O / 7 h / Heating

4: 91 percent / DCC; DMAP / CH₂Cl₂ / 3 h / 25 °C

5: 36 percent / 1-methyl-pyrrolidin-2-one / 48 h / 90 °C

With dmap; lithium hydroxide; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; toluene; 1: Diels-Alder reaction;
DOI:10.1016/S0040-4020(01)00129-6

Reference yield:

: 10034-09-0
1-methoxy-1,3-butadiene

: 345894-52-2
(1S,2S)-[1-benzamido-2-methoxycyclohexane-1-carboxamido]-(S)-phenylalanine cyclohexylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / toluene / 144 h / 85 °C

2: 99 percent / H₂ / Pd-C / methanol / 6 h / 25 °C

3: 93 percent / LiOH*H₂O / methanol; H₂O / 7 h / Heating

4: 91 percent / DCC; DMAP / CH₂Cl₂ / 3 h / 25 °C

5: 36 percent / 1-methyl-pyrrolidin-2-one / 48 h / 90 °C

With dmap; lithium hydroxide; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; toluene; 1: Diels-Alder reaction;
DOI:10.1016/S0040-4020(01)00129-6