dimethylcarbamic acid 3-{3-(aminosulfonyl)aminobenzyl}-6-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester

Base Information

Chemical Name:dimethylcarbamic acid 3-{3-(aminosulfonyl)aminobenzyl}-6-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester
CAS No.:946127-90-8
Molecular Formula:C₂₀H₂₀ClN₃O₆S
Molecular Weight:465.914
Hs Code.:

Synonyms:dimethylcarbamic acid 3-{3-(aminosulfonyl)aminobenzyl}-6-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester

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Chemical Property of dimethylcarbamic acid 3-{3-(aminosulfonyl)aminobenzyl}-6-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester

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Technology Process of dimethylcarbamic acid 3-{3-(aminosulfonyl)aminobenzyl}-6-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester

There total 5 articles about dimethylcarbamic acid 3-{3-(aminosulfonyl)aminobenzyl}-6-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 393810-61-2
dimethylcarbamic acid 2-oxo-2H-3-(3-aminobenzyl)-4-methyl-6-chloro-1-benzopyran-7-yl ester

: 946127-90-8
dimethylcarbamic acid 3-{3-(aminosulfonyl)aminobenzyl}-6-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester

Guidance literature:: With pyridine; formic acid; isocyanate de chlorosulfonyle; In dichloromethane; at 0 - 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2013.10.001

Reference yield:

: 95-88-5
4-Chlororesorcinol

: 946127-90-8
dimethylcarbamic acid 3-{3-(aminosulfonyl)aminobenzyl}-6-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / water / 12 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 5 h / 20 °C / Inert atmosphere

3.1: tin(II) chloride dihdyrate / ethyl acetate / 7 h / 80 °C

4.1: isocyanate de chlorosulfonyle; formic acid; pyridine / dichloromethane / 18 h / 0 - 20 °C

With pyridine; formic acid; isocyanate de chlorosulfonyle; tin(II) chloride dihdyrate; sulfuric acid; sodium hydride; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil; 1.1: |Pechmann Condensation;
DOI:10.1016/j.bmcl.2013.10.001

Reference yield:

: 393812-71-0
3-(3-nitrobenzyl)-7-hydroxy-4-methyl-6-chloro-2-oxo-2H-1-benzopyran

: 946127-90-8
dimethylcarbamic acid 3-{3-(aminosulfonyl)aminobenzyl}-6-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 5 h / 20 °C / Inert atmosphere

2.1: tin(II) chloride dihdyrate / ethyl acetate / 7 h / 80 °C

3.1: isocyanate de chlorosulfonyle; formic acid; pyridine / dichloromethane / 18 h / 0 - 20 °C

With pyridine; formic acid; isocyanate de chlorosulfonyle; tin(II) chloride dihdyrate; sodium hydride; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2013.10.001