N,N'-Bis{2,4-diiodo-5-[1-acetoxy-2-(dimethoxyphosphoryl)ethyl]phenyl}succinamide

Base Information

Chemical Name:N,N'-Bis{2,4-diiodo-5-[1-acetoxy-2-(dimethoxyphosphoryl)ethyl]phenyl}succinamide
CAS No.:303183-42-8
Molecular Formula:C₂₈H₃₄I₄N₂O₁₂P₂
Molecular Weight:1160.15
Hs Code.:

Synonyms:N,N'-Bis{2,4-diiodo-5-[1-acetoxy-2-(dimethoxyphosphoryl)ethyl]phenyl}succinamide

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Chemical Property of N,N'-Bis{2,4-diiodo-5-[1-acetoxy-2-(dimethoxyphosphoryl)ethyl]phenyl}succinamide

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Technology Process of N,N'-Bis{2,4-diiodo-5-[1-acetoxy-2-(dimethoxyphosphoryl)ethyl]phenyl}succinamide

There total 5 articles about N,N'-Bis{2,4-diiodo-5-[1-acetoxy-2-(dimethoxyphosphoryl)ethyl]phenyl}succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 543-20-4
succinoyl dichloride

: 303183-33-7
Dimethyl 2-acetoxy-2-(2,4-diiodo-5-aminophenyl)ethylphosphonate

: 303183-42-8
N,N'-Bis{2,4-diiodo-5-[1-acetoxy-2-(dimethoxyphosphoryl)ethyl]phenyl}succinamide

Guidance literature:: With pyridine; at 20 ℃; for 24h;
DOI:10.1039/a909086j

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 303183-42-8
N,N'-Bis{2,4-diiodo-5-[1-acetoxy-2-(dimethoxyphosphoryl)ethyl]phenyl}succinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / hexane; tetrahydrofuran / -78 °C

1.2: 97 percent / hexane; tetrahydrofuran / 1 h / -78 - 20 °C

2.1: 100 percent / pyridine / 20 °C

3.1: 99 percent / H₂ / 10percent Pd/C / ethanol / 4 h / 3800.26 Torr

4.1: 60 percent / ICl; CH₃COOH / 2.17 h / 20 - 80 °C

5.1: 46 percent / pyridine / 24 h / 20 °C

With pyridine; n-butyllithium; hydrogen; Iodine monochloride; acetic acid; 10percent Pd/C; In tetrahydrofuran; ethanol; hexane; 1.1: Metallation / 1.2: Addition / 2.1: Acetylation / 3.1: Catalytic hydrogenation / 4.1: Iodination / 5.1: Acylation;
DOI:10.1039/a909086j

Reference yield:

: 161869-28-9
dimethyl (RS)-2-hydroxy-2-(3-nitrophenyl)ethylphosphonate

: 303183-42-8
N,N'-Bis{2,4-diiodo-5-[1-acetoxy-2-(dimethoxyphosphoryl)ethyl]phenyl}succinamide

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / pyridine / 20 °C

2: 99 percent / H₂ / 10percent Pd/C / ethanol / 4 h / 3800.26 Torr

3: 60 percent / ICl; CH₃COOH / 2.17 h / 20 - 80 °C

4: 46 percent / pyridine / 24 h / 20 °C

With pyridine; hydrogen; Iodine monochloride; acetic acid; 10percent Pd/C; In ethanol; 1: Acetylation / 2: Catalytic hydrogenation / 3: Iodination / 4: Acylation;
DOI:10.1039/a909086j