10a-(4-chlorophenyl)-8-(pyridin-4-yl)-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one

Base Information

Chemical Name:10a-(4-chlorophenyl)-8-(pyridin-4-yl)-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one
CAS No.:1323076-83-0
Molecular Formula:C₂₀H₁₇ClN₄O
Molecular Weight:364.834
Hs Code.:

Synonyms:10a-(4-chlorophenyl)-8-(pyridin-4-yl)-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one

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Chemical Property of 10a-(4-chlorophenyl)-8-(pyridin-4-yl)-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one

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Technology Process of 10a-(4-chlorophenyl)-8-(pyridin-4-yl)-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one

There total 5 articles about 10a-(4-chlorophenyl)-8-(pyridin-4-yl)-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1323076-42-1
10a-(4-chlorophenyl)-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one

: 1692-15-5
4-pyridylboronic acid

: C₂₀H₁₇ClN₄O

: 1323076-83-0
10a-(4-chlorophenyl)-8-(pyridin-4-yl)-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one

Guidance literature:: 10a-(4-chlorophenyl)-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one; With N-Bromosuccinimide; In tetrahydrofuran; at 20 ℃; for 1h;

4-pyridylboronic acid; With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; ethanol; water; at 150 ℃; for 0.166667h; Microwave irradiation; Sealed tube;

Reference yield:

: 1193-62-0
methyl Pyrrole-2-carboxylate

: C₂₀H₁₇ClN₄O

: 1323076-83-0
10a-(4-chlorophenyl)-8-(pyridin-4-yl)-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 20 °C

1.2: 18 h / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

2.2: pH 2

3.1: 1,2-dichloro-ethane / Reflux

4.1: N-Bromosuccinimide / tetrahydrofuran / 1 h / 20 °C

4.2: 0.17 h / 150 °C / Microwave irradiation; Sealed tube

With N-Bromosuccinimide; water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 86289-14-7
methyl 1-[2-(4-chlorophenyl)-2-oxoethyl]-1H-pyrrole-2-carboxylate

: C₂₀H₁₇ClN₄O

: 1323076-83-0
10a-(4-chlorophenyl)-8-(pyridin-4-yl)-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

1.2: pH 2

2.1: 1,2-dichloro-ethane / Reflux

3.1: N-Bromosuccinimide / tetrahydrofuran / 1 h / 20 °C

3.2: 0.17 h / 150 °C / Microwave irradiation; Sealed tube

With N-Bromosuccinimide; water; lithium hydroxide; In tetrahydrofuran; 1,2-dichloro-ethane;