Cbz-ΔLeu-Ala-OMe

Base Information

• Chemical Name: Cbz-ΔLeu-Ala-OMe
• CAS No.: 174191-69-6
• Molecular Formula: C₁₈H₂₄N₂O₅
• Molecular Weight: 348.399

Synonyms:Cbz-ΔLeu-Ala-OMe

Chemical Property of Cbz-ΔLeu-Ala-OMe

Chemical Property:

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Technology Process of Cbz-ΔLeu-Ala-OMe

There total 1 articles about Cbz-ΔLeu-Ala-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

L-Alanine methyl ester (10065-72-2) + (Z)-2-Benzyloxycarbonylamino-4-methyl-pent-2-enoic acid (118609-93-1,72015-60-2) → Cbz-ΔLeu-Ala-OMe (174191-69-6)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at -10 ℃;

DOI:10.1246/bcsj.68.3549

Reference yield: 100.0%

Cbz-ΔLeu-Ala-OMe (174191-69-6) → (S)-2-((Z)-2-Benzyloxycarbonylamino-4-methyl-pent-2-enoylamino)-propionic acid

Guidance literature:

With McIlvaine buffer; 2-hydroxyethanethiol; at 35 ℃; for 24h; pH: 8.0, papain;

DOI:10.1246/bcsj.68.3549

Reference yield: 96.0%

H-(L)-Leu-ΔVal-OMe (87363-86-8) + Cbz-ΔLeu-Ala-OMe (174191-69-6) → 2-{(S)-2-[(S)-2-((Z)-2-Benzyloxycarbonylamino-4-methyl-pent-2-enoylamino)-propionylamino]-4-methyl-pentanoylamino}-3-methyl-but-2-enoic acid methyl ester

Guidance literature:

With McIlvaine buffer; 2-hydroxyethanethiol; at 35 ℃; for 24h; pH: 6.0, papain;

DOI:10.1246/bcsj.68.3549

upstream raw materials:

L-Alanine methyl ester

(Z)-2-Benzyloxycarbonylamino-4-methyl-pent-2-enoic acid

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