N-{6-[2-(5-bromopyrimidin-2-yloxy)ethoxy]-5-(2-methoxy-phenoxy)-2-methylsulfonylpyrimidin-4-yl}-4-tert-butylbenzenesulfonamide

Base Information

Chemical Name:N-{6-[2-(5-bromopyrimidin-2-yloxy)ethoxy]-5-(2-methoxy-phenoxy)-2-methylsulfonylpyrimidin-4-yl}-4-tert-butylbenzenesulfonamide
CAS No.:184779-27-9
Molecular Formula:C₂₈H₃₀BrN₅O₈S₂
Molecular Weight:708.611
Hs Code.:

Synonyms:N-{6-[2-(5-bromopyrimidin-2-yloxy)ethoxy]-5-(2-methoxy-phenoxy)-2-methylsulfonylpyrimidin-4-yl}-4-tert-butylbenzenesulfonamide

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Chemical Property of N-{6-[2-(5-bromopyrimidin-2-yloxy)ethoxy]-5-(2-methoxy-phenoxy)-2-methylsulfonylpyrimidin-4-yl}-4-tert-butylbenzenesulfonamide

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Technology Process of N-{6-[2-(5-bromopyrimidin-2-yloxy)ethoxy]-5-(2-methoxy-phenoxy)-2-methylsulfonylpyrimidin-4-yl}-4-tert-butylbenzenesulfonamide

There total 8 articles about N-{6-[2-(5-bromopyrimidin-2-yloxy)ethoxy]-5-(2-methoxy-phenoxy)-2-methylsulfonylpyrimidin-4-yl}-4-tert-butylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 184778-95-8
N-{6-[2-(5-bromopyrimidin-2-yloxy)ethoxy]-5-(2-methoxyphenoxy)-2-methylthiopyrimidin-4-yl}-4-tert-butylbenzene-sulfonamide

: 184779-27-9
N-{6-[2-(5-bromopyrimidin-2-yloxy)ethoxy]-5-(2-methoxy-phenoxy)-2-methylsulfonylpyrimidin-4-yl}-4-tert-butylbenzenesulfonamide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 20 ℃; for 3h;
DOI:10.1016/S0960-894X(01)00682-5

Reference yield:

: 20730-58-9
2-(2-Methoxyphenoxy)propanedioic acid diethyl ester

: 184779-27-9
N-{6-[2-(5-bromopyrimidin-2-yloxy)ethoxy]-5-(2-methoxy-phenoxy)-2-methylsulfonylpyrimidin-4-yl}-4-tert-butylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaOMe / methanol / 16 h / 20 °C

1.2: 90 percent / aq. K₂CO₃ / 3 h / 20 °C

2.1: POCl₃; PhNMe₂ / Heating

3.1: K₂CO₃ / dimethylsulfoxide / 80 °C

4.1: NaH / 100 °C

5.1: NaH / tetrahydrofuran; N,N-dimethyl-acetamide / 20 °C

6.1: 79 percent / mCPBA / CHCl₃ / 3 h / 20 °C

With sodium methylate; sodium hydride; potassium carbonate; N,N-dimethyl-aniline; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl acetamide; dimethyl sulfoxide;
DOI:10.1016/S0960-894X(01)00682-5

Reference yield:

: 6292-59-7
4-tert-butylbenzenesulphonamide

: 184779-27-9
N-{6-[2-(5-bromopyrimidin-2-yloxy)ethoxy]-5-(2-methoxy-phenoxy)-2-methylsulfonylpyrimidin-4-yl}-4-tert-butylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylsulfoxide / 80 °C

2: NaH / 100 °C

3: NaH / tetrahydrofuran; N,N-dimethyl-acetamide / 20 °C

4: 79 percent / mCPBA / CHCl₃ / 3 h / 20 °C

With sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; chloroform; N,N-dimethyl acetamide; dimethyl sulfoxide;
DOI:10.1016/S0960-894X(01)00682-5