5-(4-Chloro-phenylcarbamoyloxy)-[1,3]oxathiolane-2,2-dicarboxylic acid diethyl ester

Base Information

• Chemical Name: 5-(4-Chloro-phenylcarbamoyloxy)-[1,3]oxathiolane-2,2-dicarboxylic acid diethyl ester
• CAS No.: 191857-96-2
• Molecular Formula: C₁₆H₁₈ClNO₇S
• Molecular Weight: 403.84

Synonyms:5-(4-Chloro-phenylcarbamoyloxy)-[1,3]oxathiolane-2,2-dicarboxylic acid diethyl ester

Chemical Property of 5-(4-Chloro-phenylcarbamoyloxy)-[1,3]oxathiolane-2,2-dicarboxylic acid diethyl ester

Chemical Property:

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Technology Process of 5-(4-Chloro-phenylcarbamoyloxy)-[1,3]oxathiolane-2,2-dicarboxylic acid diethyl ester

There total 2 articles about 5-(4-Chloro-phenylcarbamoyloxy)-[1,3]oxathiolane-2,2-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Diethyl ketomalonate (609-09-6) → 5-(4-Chloro-phenylcarbamoyloxy)-[1,3]oxathiolane-2,2-dicarboxylic acid diethyl ester (191857-96-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 0.25 h / 70 °C

2: DIEA / CH₂Cl₂

With N-ethyl-N,N-diisopropylamine; In pyridine; dichloromethane;

DOI:10.1016/S0960-894X(97)00245-X

Reference yield:

p-chlorphenylisocyanate (104-12-1) + 2,2-diethoxycarbonyl-5-hydroxyoxathiolane → 5-(4-Chloro-phenylcarbamoyloxy)-[1,3]oxathiolane-2,2-dicarboxylic acid diethyl ester (191857-96-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; Yield given;

DOI:10.1016/S0960-894X(97)00245-X

Reference yield: 90.0%

5-(4-Chloro-phenylcarbamoyloxy)-[1,3]oxathiolane-2,2-dicarboxylic acid diethyl ester (191857-96-2) → (4-Chloro-phenyl)-carbamic acid 2,2-bis-hydroxymethyl-[1,3]oxathiolan-5-yl ester (191857-97-3)

Guidance literature:

With sodium tetrahydroborate; In methanol; dichloromethane;

DOI:10.1016/S0960-894X(97)00245-X

upstream raw materials:

p-chlorphenylisocyanate

Diethyl ketomalonate

Downstream raw materials:

(4-Chloro-phenyl)-carbamic acid 2,2-bis-hydroxymethyl-[1,3]oxathiolan-5-yl ester

(4-Chloro-phenyl)-carbamic acid 2,2-bis-(tert-butyl-dimethyl-silanyloxymethyl)-[1,3]oxathiolan-5-yl ester

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