{(2R,4aR,6S,7R,8R,8aS)-6-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl}-carbamic acid 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyl ester

Base Information

Chemical Name:{(2R,4aR,6S,7R,8R,8aS)-6-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl}-carbamic acid 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyl ester
CAS No.:881425-84-9
Molecular Formula:C₃₂H₃₇BrF₁₇NO₇Si
Molecular Weight:978.611
Hs Code.:

{(2R,4aR,6S,7R,8R,8aS)-6-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl}-carbamic acid 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyl ester

Synonyms:{(2R,4aR,6S,7R,8R,8aS)-6-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl}-carbamic acid 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyl ester

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Chemical Property of {(2R,4aR,6S,7R,8R,8aS)-6-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl}-carbamic acid 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyl ester

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Technology Process of {(2R,4aR,6S,7R,8R,8aS)-6-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl}-carbamic acid 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyl ester

There total 4 articles about {(2R,4aR,6S,7R,8R,8aS)-6-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl}-carbamic acid 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 881425-83-8
{(3R,4R,5S,6R)-2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-4,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-3-yl}-carbamic acid 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyl ester

: 1125-88-8
benzaldehyde dimethyl acetal

: 881425-84-9
{(2R,4aR,6S,7R,8R,8aS)-6-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl}-carbamic acid 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyl ester

Guidance literature:: With camphor-10-sulfonic acid; In acetonitrile; at 20 ℃; for 3h;
DOI:10.1021/ol060006e

Reference yield:

: Acetic acid (2R,3S,4R,5R)-3-acetoxy-2-acetoxymethyl-5-(2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyloxycarbonylamino)-6-hydroxy-tetrahydro-pyran-4-yl ester

: 881425-84-9
{(2R,4aR,6S,7R,8R,8aS)-6-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl}-carbamic acid 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / imidazole / dimethylformamide / 12 h / 20 °C

2: sodium methoxide / methanol / 2 h / 20 °C

3: 72 percent / camphorsulfonic acid / acetonitrile / 3 h / 20 °C

With 1H-imidazole; camphor-10-sulfonic acid; sodium methylate; In methanol; N,N-dimethyl-formamide; acetonitrile; 2: Zemplen deacetylation;
DOI:10.1021/ol060006e

Reference yield:

: 881425-82-7
Acetic acid (2R,3S,4R,5R)-3-acetoxy-2-acetoxymethyl-5-(2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyloxycarbonylamino)-6-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-tetrahydro-pyran-4-yl ester

: 881425-84-9
{(2R,4aR,6S,7R,8R,8aS)-6-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl}-carbamic acid 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methoxide / methanol / 2 h / 20 °C

2: 72 percent / camphorsulfonic acid / acetonitrile / 3 h / 20 °C

With camphor-10-sulfonic acid; sodium methylate; In methanol; acetonitrile; 1: Zemplen deacetylation;
DOI:10.1021/ol060006e