(E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

Base Information

Chemical Name:(E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid
CAS No.:1421923-96-7
Molecular Formula:C₁₃H₇F₆N₃O₂
Molecular Weight:351.208
Hs Code.:

Synonyms:(E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

Suppliers and Price of (E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of (E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

Chemical Property:

Purity/Quality:: 99%+, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of (E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

There total 6 articles about (E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1388842-43-0
isopropyl 3-iodoacrylate

: 1333154-10-1
3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazole

: 1388842-44-1
(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

: 1421923-96-7
(E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

Guidance literature:: isopropyl 3-iodoacrylate; 3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazole; With 1,4-diaza-bicyclo[2.2.2]octane; N-ethyl-N,N-diisopropylamine; In 2-methyltetrahydrofuran; at 20 - 25 ℃; for 16h; Inert atmosphere; Large scale;

With water; potassium hydroxide; In isopropyl alcohol; at 20 - 25 ℃; for 3h; Temperature; Solvent; Reagent/catalyst; Inert atmosphere; Large scale;

Reference yield: 61.6%

: 1421923-95-6
(E)-isopropyl 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

: 1421923-96-7
(E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

Guidance literature:: With water; lithium hydroxide; at 20 ℃; for 4h;

Reference yield:

: 1333154-10-1
3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazole

: 1421923-96-7
(E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,4-diaza-bicyclo[2.2.2]octane / N,N-dimethyl-formamide / 0.5 h

1.2: 1 h

2.1: lithium hydroxide; water / 4 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; water; lithium hydroxide; In N,N-dimethyl-formamide;