2-(ETHYLTHIO)NICOTINIC ACID

Base Information

• Chemical Name: 2-(ETHYLTHIO)NICOTINIC ACID
• CAS No.: 27868-76-4
• Molecular Formula: C8H9 N O2 S
• Molecular Weight: 183.23
• Hs Code.: 29339900
• Mol file: 27868-76-4.mol

Synonyms:Nicotinicacid, 2-(ethylthio)- (8CI); 2-(Ethylthio)nicotinic acid;2-(Ethylthio)pyridine-3-carboxylic acid; 2-Ethylsulfanylpyridine-3-carboxylicacid

Chemical Property of 2-(ETHYLTHIO)NICOTINIC ACID

Chemical Property:

• Vapor Pressure: 3.78E-05mmHg at 25°C
• Melting Point: 185 °C
• Boiling Point: 338.6°C at 760 mmHg
• Flash Point: 158.6°C
• PSA: 75.49000
• Density: 1.3g/cm³
• LogP: 1.89180

Purity/Quality:

99% ^*data from raw suppliers

2-(Ethylthio)nicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi:Irritant
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(ETHYLTHIO)NICOTINIC ACID

There total 1 articles about 2-(ETHYLTHIO)NICOTINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

→ 2-ethylsulfanylnicotinic acid (27868-76-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 5 ℃; for 0.5h;

In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h;

Reference yield:

(S)-3-{[1-(4-cyanobenzyl)-1H-imidazol-5-ylmethyl]amino}pyrrolidine hydrochloride + 2-ethylsulfanylnicotinic acid (27868-76-4) → 4-(5-{[(S)-1-(2-Ethylsulfanyl-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile

Guidance literature:

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxybenzotriazol-hydrate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1021/jm010156p

Refernces