4-tert-butyl-N-(6-(2-((5-formyl-2-pyrimidinyl)oxy)ethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)benzenesulfonamide

Base Information

• Chemical Name: 4-tert-butyl-N-(6-(2-((5-formyl-2-pyrimidinyl)oxy)ethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)benzenesulfonamide
• CAS No.: 169679-11-2
• Molecular Formula: C₂₈H₂₉N₅O₅S
• Molecular Weight: 547.635

Synonyms:4-tert-butyl-N-(6-(2-((5-formyl-2-pyrimidinyl)oxy)ethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)benzenesulfonamide

Chemical Property of 4-tert-butyl-N-(6-(2-((5-formyl-2-pyrimidinyl)oxy)ethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)benzenesulfonamide

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Technology Process of 4-tert-butyl-N-(6-(2-((5-formyl-2-pyrimidinyl)oxy)ethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)benzenesulfonamide

There total 2 articles about 4-tert-butyl-N-(6-(2-((5-formyl-2-pyrimidinyl)oxy)ethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + N-[6-{2-(5-Bromopyrimidin-2-yloxy)ethoxy}-5-(4-methylphenyl)-pyrimidin-4-yl]-4-tert-butylbenzenesulfonamide (169677-30-9) → 4-tert-butyl-N-(6-(2-((5-formyl-2-pyrimidinyl)oxy)ethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)benzenesulfonamide (169679-11-2)

Guidance literature:

N-[6-{2-(5-Bromopyrimidin-2-yloxy)ethoxy}-5-(4-methylphenyl)-pyrimidin-4-yl]-4-tert-butylbenzenesulfonamide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Further stages.;

DOI:10.1021/jm000538f

Reference yield:

ammonium chloride + N-[6-{2-(5-Bromopyrimidin-2-yloxy)ethoxy}-5-(4-methylphenyl)-pyrimidin-4-yl]-4-tert-butylbenzenesulfonamide (169677-30-9) → 4-tert-butyl-N-(6-(2-((5-formyl-2-pyrimidinyl)oxy)ethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)benzenesulfonamide (169679-11-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; N-methyl-acetamide; hexane;

Reference yield: 67.0%

4-tert-butyl-N-(6-(2-((5-formyl-2-pyrimidinyl)oxy)ethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)benzenesulfonamide (169679-11-2) → 4-tert-butyl-N-[6-{2-(5-hydroxymethylpyrimidin-2-yloxy)ethoxy}-5-(4-methylphenyl)pyrimidin-4-yl]benzenesulfonamide

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; isopropyl alcohol; at 0 ℃; for 2h;

DOI:10.1021/jm000538f

upstream raw materials:

N,N-dimethyl-formamide

N-[6-{2-(5-Bromopyrimidin-2-yloxy)ethoxy}-5-(4-methylphenyl)-pyrimidin-4-yl]-4-tert-butylbenzenesulfonamide

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