N₅-(5-(9H-purin-6-yl)pyrimidin-4-yl)-N₁-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine

Base Information

• Chemical Name: N₅-(5-(9H-purin-6-yl)pyrimidin-4-yl)-N₁-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine
• CAS No.: 1093100-49-2
• Molecular Formula: C₂₅H₁₈ClN₉
• Molecular Weight: 479.931

Synonyms:N₅-(5-(9H-purin-6-yl)pyrimidin-4-yl)-N₁-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine

Chemical Property of N₅-(5-(9H-purin-6-yl)pyrimidin-4-yl)-N₁-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine

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Technology Process of N₅-(5-(9H-purin-6-yl)pyrimidin-4-yl)-N₁-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine

There total 3 articles about N₅-(5-(9H-purin-6-yl)pyrimidin-4-yl)-N₁-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine (1093101-72-4) + 6-(4-chloropyrimidin-5-yl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine (1093101-61-1) → N5-(5-(9H-purin-6-yl)pyrimidin-4-yl)-N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine (1093100-49-2)

Guidance literature:

In N,N-dimethyl-formamide; at 70 - 90 ℃;

Reference yield:

6-iodopurine (2545-26-8) → N5-(5-(9H-purin-6-yl)pyrimidin-4-yl)-N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine (1093100-49-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / ethyl acetate / 2 h / Heating / reflux

2.1: TurboGrignard / tetrahydrofuran / 0.58 h / -40 °C

2.2: -40 - 20 °C

2.3: 16 h / 60 °C

3.1: N,N-dimethyl-formamide / 70 - 90 °C

With TurboGrignard; toluene-4-sulfonic acid; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

6-iodo-9-(tetrahydro-2H-pyran-2-yl)-9H-purine (71819-06-2) → N5-(5-(9H-purin-6-yl)pyrimidin-4-yl)-N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine (1093100-49-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: TurboGrignard / tetrahydrofuran / 0.58 h / -40 °C

1.2: -40 - 20 °C

1.3: 16 h / 60 °C

2.1: N,N-dimethyl-formamide / 70 - 90 °C

With TurboGrignard; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

N¹-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine

6-(4-chloropyrimidin-5-yl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

6-iodopurine

6-iodo-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

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