4-(Cyclopentyloxy)benzaldehyde

Base Information

• Chemical Name: 4-(Cyclopentyloxy)benzaldehyde
• CAS No.: 164520-98-3
• Molecular Formula: C₁₂H₁₄O₂
• Molecular Weight: 190.242
• DSSTox Substance ID: DTXSID90390008
• Wikidata: Q82186361
• Mol file: 164520-98-3.mol

Synonyms:4-(cyclopentyloxy)benzaldehyde;164520-98-3;4-Cyclopentyloxy-benzaldehyde;4-cyclopentyloxybenzaldehyde;SCHEMBL510213;DTXSID90390008;YURIAUHHAZFYPA-UHFFFAOYSA-N;BBL036249;MFCD04133155;STK499877;AKOS000103252;SB85366;AS-60269;BP-10495;4-(Cyclopentyloxy)benzaldehyde, AldrichCPR;BB 0243270;C77950;EN300-239870;F6511-8579

Chemical Property of 4-(Cyclopentyloxy)benzaldehyde

Chemical Property:

• Vapor Pressure: 0.000286mmHg at 25°C
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 190.099379685
• Heavy Atom Count: 14
• Complexity: 177

Purity/Quality:

97% ^*data from raw suppliers

4-(Cyclopentyloxy)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(C1)OC2=CC=C(C=C2)C=O
• Uses: 4-(Cyclopentyloxy)benzaldehyde is used for preparation of rhodanine derivatives as inhibitors of PDE4.

Technology Process of 4-(Cyclopentyloxy)benzaldehyde

There total 3 articles about 4-(Cyclopentyloxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Cyclopentyl bromide (137-43-9) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-(cyclopentyloxy)benzaldehyde (164520-98-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 65 - 100 ℃;

DOI:10.1016/j.ejmech.2016.10.047

Reference yield: 56.0%

Cyclopentanol (96-41-3) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-(cyclopentyloxy)benzaldehyde (164520-98-3)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield:

Cyclopentanol (96-41-3) + 4-fluorobenzaldehyde (459-57-4) → 4-(cyclopentyloxy)benzaldehyde (164520-98-3)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; for 30h; Reflux;

DOI:10.2174/1386207311316030009

upstream raw materials:

Cyclopentanol

4-hydroxy-benzaldehyde

Cyclopentyl bromide

4-fluorobenzaldehyde

Downstream raw materials:

1-cyclopentyloxy-4-((E)-2-nitro-vinyl)-benzene

C₁₉H₁₉N₃OS