2-(2-{2-[2-(2-amino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-butyrylamino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid

Base Information

• Chemical Name: 2-(2-{2-[2-(2-amino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-butyrylamino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid
• CAS No.: 934715-80-7
• Molecular Formula: C₃₁H₅₁N₅O₆
• Molecular Weight: 589.776
• Mol file: 934715-80-7.mol

Synonyms:2-(2-{2-[2-(2-amino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-butyrylamino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid

Chemical Property of 2-(2-{2-[2-(2-amino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-butyrylamino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-{2-[2-(2-amino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-butyrylamino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid

There total 10 articles about 2-(2-{2-[2-(2-amino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-butyrylamino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → 2-(2-{2-[2-(2-amino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-butyrylamino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid (934715-80-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / ethyldiisopropylamine; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium BF₄ / CH₂Cl₂ / 20 °C

2: 98 percent / lithium hydroxide / methanol

3: 60 percent / ethyldiisopropylamine; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium BF₄; 2-(1H-7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium PF₆ / acetonitrile / 20 °C

4: HCl; anisole / tetrahydrofuran

With hydrogenchloride; lithium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

DOI:10.1021/jo061830j

Reference yield:

2-(2-{2-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-butyrylamino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid methyl ester (934715-44-3) → 2-(2-{2-[2-(2-amino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-butyrylamino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid (934715-80-7)

Guidance literature:

With hydrogenchloride; methoxybenzene; In tetrahydrofuran;

DOI:10.1021/jo061830j

Reference yield:

2-[2-(2-amino-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid methyl ester (934715-43-2) → 2-(2-{2-[2-(2-amino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-butyrylamino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid (934715-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / ethyldiisopropylamine; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium BF₄; 2-(1H-7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium PF₆ / acetonitrile / 20 °C

2: HCl; anisole / tetrahydrofuran

With hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jo061830j

upstream raw materials:

2-(2-{2-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-butyrylamino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid methyl ester

2-[2-(2-amino-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid methyl ester

2-[2-(2-tert-butoxycarbonylamino-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid methyl ester

N-tert-butoxycarbonyl-L-leucine