methyl [4-(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)piperazin-1-yl]acetate

Base Information

• Chemical Name: methyl [4-(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)piperazin-1-yl]acetate
• CAS No.: 1610549-53-5
• Molecular Formula: C₂₅H₂₄N₄O₃
• Molecular Weight: 428.491

Synonyms:methyl [4-(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)piperazin-1-yl]acetate

Chemical Property of methyl [4-(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)piperazin-1-yl]acetate

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Technology Process of methyl [4-(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)piperazin-1-yl]acetate

There total 2 articles about methyl [4-(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)piperazin-1-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5,6-diphenyl-4-piperazin-1-ylfuro[2,3-d]pyrimidine (1610549-49-9) + bromoacetic acid methyl ester (96-32-2) → methyl [4-(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)piperazin-1-yl]acetate (1610549-53-5)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 0.0833333h; Inert atmosphere;

DOI:10.1002/cmdc.201300571

Reference yield:

4-chloro-5,6-diphenylfuro[2,3-d]pyrimidine (65148-07-4) → methyl [4-(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)piperazin-1-yl]acetate (1610549-53-5)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 8 h / 80 °C / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / 0.08 h / 60 °C / Inert atmosphere

With triethylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201300571

Reference yield: 98.0%

methyl [4-(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)piperazin-1-yl]acetate (1610549-53-5) → [4-(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)piperazin-1-yl]acetic acid (1610549-54-6)

Guidance literature:

With lithium hydroxide; In methanol; water; at 60 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1002/cmdc.201300571

upstream raw materials:

4-chloro-5,6-diphenylfuro[2,3-d]pyrimidine

5,6-diphenyl-4-piperazin-1-ylfuro[2,3-d]pyrimidine

bromoacetic acid methyl ester

Downstream raw materials:

2-[4-(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-N-(3-fluorophenyl)acetamide

[4-(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)piperazin-1-yl]acetic acid

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