(1S,2S,3R,4R)-2-benzo[d][1,3]dioxol-5-yl-1-{[(tert-butyldimethylsilyl)oxy]methyl}-4-[2-(4-methoxyphenyloxy)-2-oxoethyl]-3-nitrocyclohexane

Base Information

Chemical Name:(1S,2S,3R,4R)-2-benzo[d][1,3]dioxol-5-yl-1-{[(tert-butyldimethylsilyl)oxy]methyl}-4-[2-(4-methoxyphenyloxy)-2-oxoethyl]-3-nitrocyclohexane
CAS No.:1646294-26-9
Molecular Formula:C₂₉H₃₉NO₈Si
Molecular Weight:557.716
Hs Code.:

Synonyms:(1S,2S,3R,4R)-2-benzo[d][1,3]dioxol-5-yl-1-{[(tert-butyldimethylsilyl)oxy]methyl}-4-[2-(4-methoxyphenyloxy)-2-oxoethyl]-3-nitrocyclohexane

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Chemical Property of (1S,2S,3R,4R)-2-benzo[d][1,3]dioxol-5-yl-1-{[(tert-butyldimethylsilyl)oxy]methyl}-4-[2-(4-methoxyphenyloxy)-2-oxoethyl]-3-nitrocyclohexane

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Technology Process of (1S,2S,3R,4R)-2-benzo[d][1,3]dioxol-5-yl-1-{[(tert-butyldimethylsilyl)oxy]methyl}-4-[2-(4-methoxyphenyloxy)-2-oxoethyl]-3-nitrocyclohexane

There total 3 articles about (1S,2S,3R,4R)-2-benzo[d][1,3]dioxol-5-yl-1-{[(tert-butyldimethylsilyl)oxy]methyl}-4-[2-(4-methoxyphenyloxy)-2-oxoethyl]-3-nitrocyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1646294-25-8
(1S,2S,3R,4R)-2-benzo[d][1,3]dioxol-5-yl-1-{[(tert-butyldimethylsilyl)oxy]methyl}-4-[2-(4-methoxyphenyl)-2-oxoethyl]-3-nitrocyclohexane

: 1646294-26-9
(1S,2S,3R,4R)-2-benzo[d][1,3]dioxol-5-yl-1-{[(tert-butyldimethylsilyl)oxy]methyl}-4-[2-(4-methoxyphenyloxy)-2-oxoethyl]-3-nitrocyclohexane

Guidance literature:: With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 48h;
DOI:10.1002/anie.201404072

Reference yield:

: 1646295-18-2
C₂₃H₂₅NO₇

: 1646294-26-9
(1S,2S,3R,4R)-2-benzo[d][1,3]dioxol-5-yl-1-{[(tert-butyldimethylsilyl)oxy]methyl}-4-[2-(4-methoxyphenyloxy)-2-oxoethyl]-3-nitrocyclohexane

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 18 h / 0 - 20 °C

2: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48 h / 0 - 20 °C

With 1H-imidazole; dmap; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201404072

Reference yield:

: C₂₃H₂₃NO₇

: 1646294-26-9
(1S,2S,3R,4R)-2-benzo[d][1,3]dioxol-5-yl-1-{[(tert-butyldimethylsilyl)oxy]methyl}-4-[2-(4-methoxyphenyloxy)-2-oxoethyl]-3-nitrocyclohexane

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / ethanol; dichloromethane / 3 h / -78 °C

2: 1H-imidazole; dmap / N,N-dimethyl-formamide / 18 h / 0 - 20 °C

3: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48 h / 0 - 20 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201404072