2,2-Dimethyl-propionic acid (3R,4R)-6-(tert-butyl-diphenyl-silanyloxy)-4-(2-iodo-ethyl)-3-iodomethyl-hexyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (3R,4R)-6-(tert-butyl-diphenyl-silanyloxy)-4-(2-iodo-ethyl)-3-iodomethyl-hexyl ester
CAS No.:708254-76-6
Molecular Formula:C₃₀H₄₄I₂O₃Si
Molecular Weight:734.572
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (3R,4R)-6-(tert-butyl-diphenyl-silanyloxy)-4-(2-iodo-ethyl)-3-iodomethyl-hexyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (3R,4R)-6-(tert-butyl-diphenyl-silanyloxy)-4-(2-iodo-ethyl)-3-iodomethyl-hexyl ester

Chemical Property:

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Technology Process of 2,2-Dimethyl-propionic acid (3R,4R)-6-(tert-butyl-diphenyl-silanyloxy)-4-(2-iodo-ethyl)-3-iodomethyl-hexyl ester

There total 1 articles about 2,2-Dimethyl-propionic acid (3R,4R)-6-(tert-butyl-diphenyl-silanyloxy)-4-(2-iodo-ethyl)-3-iodomethyl-hexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 708254-75-5
2,2-Dimethyl-propionic acid (3R,4S)-6-(tert-butyl-diphenyl-silanyloxy)-4-(2-hydroxy-ethyl)-3-hydroxymethyl-hexyl ester

: 708254-76-6
2,2-Dimethyl-propionic acid (3R,4R)-6-(tert-butyl-diphenyl-silanyloxy)-4-(2-iodo-ethyl)-3-iodomethyl-hexyl ester

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine;
DOI:10.1016/j.tetlet.2004.03.085

Reference yield:

: 708254-76-6
2,2-Dimethyl-propionic acid (3R,4R)-6-(tert-butyl-diphenyl-silanyloxy)-4-(2-iodo-ethyl)-3-iodomethyl-hexyl ester

: 56-54-2,130-95-0,572-59-8,572-60-1,42151-59-7,47342-58-5,72402-50-7,72402-51-8,72402-52-9,72402-53-0,101143-86-6,101143-87-7,101143-88-8,146925-10-2
quinindine

Guidance literature:: Multi-step reaction with 12 steps

1.1: 98 percent / dioxane / 100 °C

2.1: 99 percent / toluene

3.1: NaOEt / ethanol / Heating

4.1: o-(NO₂)C₆H₄SeCN; PBu₃ / tetrahydrofuran

4.2: aq. H₂O₂ / tetrahydrofuran

5.1: 61 percent / MeLi / 0 °C

6.1: TBAF

7.1: PCC

8.1: 82 percent / NaH / tetrahydrofuran / 20 °C

9.1: 87 percent / AD-mix-α / 0 - 20 °C

10.1: MeC(OMe)3; PPTS / CH₂Cl₂

10.2: 88 percent / TMSCl; K₂CO₃ / methanol

11.1: DIBAL-H / toluene

12.1: DMF / 160 °C

With Trimethyl orthoacetate; AD-mix-α; ortho-nitrophenyl selenocyanate; tributylphosphine; tetrabutyl ammonium fluoride; methyllithium; sodium ethanolate; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; N,N-dimethyl-formamide; pyridinium chlorochromate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;
DOI:10.1016/j.tetlet.2004.03.085

Reference yield:

: 708254-76-6
2,2-Dimethyl-propionic acid (3R,4R)-6-(tert-butyl-diphenyl-silanyloxy)-4-(2-iodo-ethyl)-3-iodomethyl-hexyl ester

: (3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-(2-hydroxy-ethyl)-piperidine-1-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / dioxane / 100 °C

2: 99 percent / toluene

3: NaOEt / ethanol / Heating

With sodium ethanolate; In 1,4-dioxane; ethanol; toluene;
DOI:10.1016/j.tetlet.2004.03.085