3-(1-(4-carbamoyl-2-methylphenyl)-5-(5-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoic acid

Base Information

Chemical Name:3-(1-(4-carbamoyl-2-methylphenyl)-5-(5-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoic acid
CAS No.:1208316-59-9
Molecular Formula:C₂₃H₂₂N₄O₃S
Molecular Weight:434.519
Hs Code.:

Synonyms:3-(1-(4-carbamoyl-2-methylphenyl)-5-(5-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoic acid

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Chemical Property of 3-(1-(4-carbamoyl-2-methylphenyl)-5-(5-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoic acid

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Technology Process of 3-(1-(4-carbamoyl-2-methylphenyl)-5-(5-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoic acid

There total 13 articles about 3-(1-(4-carbamoyl-2-methylphenyl)-5-(5-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1170267-83-0
4-amino-3-methylbenzamide hydrochloride

: 1338799-46-4
3-(2-(3-(5-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-3-oxopropyl)-1,3-dioxolan-2-yl)propanoic acid

: 1208316-59-9
3-(1-(4-carbamoyl-2-methylphenyl)-5-(5-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoic acid

Guidance literature:: With methanesulfonic acid; In dimethyl sulfoxide; at 110 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.07.103

Reference yield: 35.0%

: 1208871-34-4
C₂₅H₂₆N₄O₃S

: 1208316-59-9
3-(1-(4-carbamoyl-2-methylphenyl)-5-(5-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2011.07.103

Reference yield:

: 527-72-0
2-thiophenylcarboxylic acid

: 1208316-59-9
3-(1-(4-carbamoyl-2-methylphenyl)-5-(5-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: bromine / acetic acid / 16 h / 20 °C

2.1: oxalyl dichloride; sodium hydrogencarbonate / dichloromethane; water; N,N-dimethyl-formamide / 0 - 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2.17 h / -55 - -25 °C

3.2: 4.33 h / -55 - -25 °C

4.1: lithium hydroxide monohydrate / water / 20 °C

5.1: copper(I) oxide; 8-quinolinol; potassium carbonate / dimethyl sulfoxide / 16 h / 110 °C / Inert atmosphere

6.1: methanesulfonic acid / dimethyl sulfoxide / 3 h / 110 °C / Inert atmosphere

With copper(I) oxide; 8-quinolinol; oxalyl dichloride; methanesulfonic acid; lithium hydroxide monohydrate; bromine; sodium hydrogencarbonate; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.07.103