(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-((tert-butyldimethylsilyloxy)methyl)-4-chloro-1H-indol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

Base Information

Chemical Name:(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-((tert-butyldimethylsilyloxy)methyl)-4-chloro-1H-indol-1-yl)acetamido)-N-methyl-3-phenylpropanamide
CAS No.:1375278-50-4
Molecular Formula:C₄₂H₅₈ClN₃O₆Si₂
Molecular Weight:792.563
Hs Code.:

(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-((tert-butyldimethylsilyloxy)methyl)-4-chloro-1H-indol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

Synonyms:(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-((tert-butyldimethylsilyloxy)methyl)-4-chloro-1H-indol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

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Chemical Property of (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-((tert-butyldimethylsilyloxy)methyl)-4-chloro-1H-indol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

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Technology Process of (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-((tert-butyldimethylsilyloxy)methyl)-4-chloro-1H-indol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

There total 7 articles about (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-((tert-butyldimethylsilyloxy)methyl)-4-chloro-1H-indol-1-yl)acetamido)-N-methyl-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1375278-49-1
(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-bromoacetamido)-N-methyl-3-phenylpropanamide

: 1375278-48-0
3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-((tert-butyldimethylsilyl-oxy)methyl)-4-chloro-1H-indole

: 1375278-50-4
(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-((tert-butyldimethylsilyloxy)methyl)-4-chloro-1H-indol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

Reference yield:

: 1375278-43-5
4-chloro-1-tosyl-1H-indole-2-carbaldehyde

: 1375278-50-4
(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-((tert-butyldimethylsilyloxy)methyl)-4-chloro-1H-indol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 20 °C

1.2: 0.5 h

2.1: potassium hydroxide / tetrahydrofuran; ethanol / 2 h / Reflux

3.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h

4.1: pyridine / tetrahydrofuran / Reflux

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux

6.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

7.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; caesium carbonate; potassium hydroxide; 1H-imidazole; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1375278-46-8
ethyl 2-(2-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-1H-indol-3-yl)-2-oxoacetate

: 1375278-50-4
(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-((tert-butyldimethylsilyloxy)methyl)-4-chloro-1H-indol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux

2: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

With lithium aluminium tetrahydride; caesium carbonate; 1H-imidazole; In tetrahydrofuran; N,N-dimethyl-formamide;